Acid-sensitive polyacetals and methods

Details Acid-sensitive polyacetals and methods Acid-sensitive polyacetals and methods

2006-05-23

2006-05-23

Acquah, Samuel A. (Department: 1711)

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

C528S332000, C528S363000, C528S364000, C528S376000, C528S392000, C528S422000, C528S425000, C525S535000, C525S540000, C514S579000, C514S609000, C514S613000, C514S716000, C514S722000, C514S723000, C424S001530, C424S179100, C530S391500, C530S402000

Reexamination Certificate

active

07048925

ABSTRACT:
Polyacetals comprising a recurring units represented by a formula selected from the group consisting of formula (I) and (II):wherein A comprises at least one acetal group; B is selected from the group consisting of —CH—, —CH(CH3)—, CH2CH—, —CH2C(CH3)—, —CH(CH3)CH—, and —CHCH(CH3)CH(CH3)—; Z is selected from the group consisting of C(O)OR1, C(O)SR1, C(O)NR1R2, and VU; V is a linker group; U is selected from the group consisting of poly(ethyleneimine), poly(propyleneimine), poly(lysine), PAMAM dendrimer, octaamine dendrimer, hexadecaamine dendrimer, enhancer, and targeting receptor; R1and R2are each individually selected from the group consisting of hydrogen, C1to C10alkyl, and C6to C10aryl; D is a linkage selected from the group consisting of carboxylic amide, carboxylic ester, urea, and urethane; and G is selected from the group consisting of C4to C20alkyl, C6-C10aryl, and —(OCH2CH2)n—, where n is in the range of 1 to about 250, are useful in nucleic acid delivery applications. In preferred embodiments, complexes formed between polyacetals of the formulae (I) or (II) and polynucleotides are useful as transfection reagents.

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