Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from a root – bulb – tuber – corm – or...
Reexamination Certificate
2006-01-31
2006-01-31
Coe, Susan (Department: 1655)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from a root, bulb, tuber, corm, or...
C424S725000
Reexamination Certificate
active
06991817
ABSTRACT:
An acid-modified arabinogalactan protein composition, having an arabinose-galactaose ratio of less than 3.5:1, comprising 5–10% Rha, 20–35% Gal, and less than 5% Glc, prepared fromAstragalus membranaceus, is useful for treating a number of conditions. For example, an acid-modified arabinogalactan protein composition having features of the invention is useful for stimulating hematopolesis, inducing the proliferation of megakaryocytes, inducing the maturation of megakaryocytes, and stimulating the production of IL-1β, IL-6, TNF-α, IFN-γ, GM-CSF, G-CSF, and neutrophils, and stimulating the action of neutrophils; stimulating the immune and/or hematopoietic system of a mammal suffering from neutropenia, anemia, thrombocytopenia, exposure to cytotoxic agents, exposure to radiation, cachexia, emesis, and drug withdrawal symptoms; and is effective to restore the immune response to infection, in immunosuppressive conditions, and to protect hepatic cells in hepatitis B.
REFERENCES:
patent: 4708949 (1987-11-01), Liu
patent: 4795742 (1989-01-01), Liu
patent: 4843067 (1989-06-01), Liu
patent: 4944946 (1990-07-01), Liu
patent: 4950751 (1990-08-01), DeWitt
patent: 5116969 (1992-05-01), Adams et al.
patent: 5268467 (1993-12-01), Verbiscar
patent: 5336506 (1994-08-01), Josephson et al.
patent: 5478576 (1995-12-01), Jung et al.
patent: 5554386 (1996-09-01), Groman et al.
patent: 5589591 (1996-12-01), Lewis
patent: 5646029 (1997-07-01), Chen et al.
patent: 5679323 (1997-10-01), Menz et al.
patent: 5756098 (1998-05-01), Price et al.
patent: 5770217 (1998-06-01), Kutilek, III et al.
patent: 5830747 (1998-11-01), Chen et al.
patent: 0 441 278 (1991-08-01), None
patent: 0 511 932 (1992-11-01), None
patent: 0 668 072 (1995-08-01), None
patent: WO 01/00682 (2001-01-01), None
Larm, O. et al.; “Structured Studies on a Water-soluble Arabinogalactan Isolated from Rapeseed (Brassica napus),” 1976, Acta Chemica Scandinavica B 30:627-630.
Dissertation Abstract International, “Identification of Immunostimulants Derived from Astragalus Membranaceus”, vol. 47, No. 7, Jan. 1987, pp. 2991. Abstract of dissertation of Michael A. McLauhglin.
Database Chemical Abstracts, Online, Chemical Abstracts Service, Columbus OH/US; AN 115:105995, XP002150924 abstract, Nov. 28, 1990. Abstract of Chinese Patent No. 1047296.
Dan Bensky et al., “Radix Astragali”,Chinese Herbal Medicine, Materia Medica, Sixth printing 1991, pp. 457-459.
Hson-Mou Chang et al., “Huangqi”,Pharmacology and Applications of Chinese Materia Medica, 1987, vol. II, pp. 1041-1046.
Da-Tong Chu et al., “Immunotherapy with Chinese Medicinal Herbs II. Reversal of Cyclophosphamide-Induced Immune Suppression by Administration of FractionatedAstragalus membrane aceusIn Vivo”,J. Clin. Lab. Immunology, 1988, pp. 25:125-129.
Da-Tong Chu et al., “Fractionated Extract ofAstragalus membranaceus, A Chinese Medicinal Herb, Potentiates lak Cell Cytotoxicity Generated by a Low Dose of Recombinant Interleukin-2”,J. Clin. Lab. Immunology, 26, 1988, pp. 4:183-187.
Quan H.X. et al., “Effects ofAstragalus membranaceuson Irradiated Animal”,Zhong Cao Yao Zazhi, 1993, pp. 24:423-425. No translation available.
Dr. Hong-Yen Hsu, “Astragali Radix”,Oriental Materia Medica a Concise Guide, 1986, pp. 521.
Shin-Ichi Miura et al., “Effect of a Traditional Chinese Herbal Medicine Ren-Shen-Yang-Rong-Tang (Japanese Name: Ninjin-Youei-To) On Hematopoietic Stem Cells In Mice”,Int. J. Immunopharmac., vol. 11, 1989, pp. 7:771-780.
Michael A. Mclaughlin, “Identification of Immunostimulants Derived fromAstragalus membranaceus”, PhD Dissertation. Abstracted at document 19.
Eugene A. Nothnagel, “Proteoglycans and Related Components in Plant Cells”,International Review of cytology, vol. 174, pp. 195-289.
Yoko Ohnishi et al., “Effects of Juzen-taiho-toh (TJ-48), a Traditional Oriental Medicine, on Hematopoietic Recovery from Radiation Injury in Mice”,International Society for Experimental Hematology, 1990, pp. 18-22.
Ma Rou et al., “The Effect of Radix Astragali on Mouse Marrow Hemopoiesis”,Journal of Traditional Chinese Medicine, 1983, 3(3): 199-204.
Jin Rui et al., “Effects of Shi-ka-ron and Chinese Herbs in Mice treated with Anti-Tumor Agent Mitomycin C”,Chung-Kuo Chung His i Chieh Ho Tsa Chih15, No. 2:101, abstract only, no translation.
Jens Sommer-Knudsen et al., “Hydroxyproline-rich plant glycoproteins”,Phytochemistry, 1998, vol. 47(4), pp. 483-497.
Yan Sun et al., “Preliminary Observations on the Effects of the Chinese Medicinal HerbsAstragalus membranaceusandLigustrum lucidumon Lymphocyte Blastogenic Responses”,Journal of Biological Responses Modifiers, 1983, vol. 2, pp. 227-237.
W. Tang et al., “Astragalus membranaceus(Fisch.) Bge.”,Chinese Drugs of Plant origin, 1992, pp. 191-197.
Quan, H. X. et al., “Effects ofAstragalus membranaceuson Hematopoiesis of Irradiated Mice”,Zhongguo Zhongyao Zazhi, 1994, pp. 19:741-743, no translation.
K.S. Zhao et al., “Enhancement of the Immune Response in Mice byAstragulus membranaceus. Extracts”,Immunopharmacolgy20, 1990, pp. 3:225-234.
K.W. Zhao et al., “Effect of Astragalan on Secretion of Tumor Necrosis Factors in Human Peripheral Blood Mononuclear Cells”,Chung-Kuo Chung His i Chieh Ho Tsa Chih13, No. 5:263-259, abstract only, no translation.
Xiao-sheng, W. et al., “Treatment of Leucopenia with Pure Astragalus Preparation—An Analysis of 115 Leucopenic cases”,Zhongguo Zhongxiyi Jieho Zazhi, Chinese J. Inter. Trad. Western Med.15, 1995, pp. 8:462-464, abstract only, no translation.
Handbook of Instrumental Techniques for Analytical chemistry, ed. Frank Settle, Chapter 46, pp. 853-866 (chapter author: David Meunier), published by Prentice-Hall, 1997 (ISBN No. 013177380).
An Jinhua
Lennox Edwin S.
Leu Karen S.
Musser John H.
Coe Susan
Fox James A.
Heller Ehrman LLP
McCormick-Ewoldt S. B.
Pharmagenesis, Inc.
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