Acid-labile subunit (ALS) of insulin-like growth factor binding

Details Acid-labile subunit (ALS) of insulin-like growth factor binding Acid-labile subunit (ALS) of insulin-like growth factor binding

1995-06-02

1999-02-02

Walsh, Stephen

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 435326, 4352523, 536 235, 536 231, 530350, C12N 1500

Patent

active

058663606

ABSTRACT:
An acid-labile protein is described that, when incubated with the 53-Kd acid-stable protein occupied by IGF, converts it to a high molecular weight complex, corresponding to the in vivo form of IGF. This protein is called the acid-labile subunit (ALS) of IGF binding protein complex and is provided in biologically pure form. ALS is useful in treating wounds and promoting cellular growth. The nucleic acid encoding ALS, antibodies binding thereto, and fragments thereof are also disclosed.

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