Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2006-10-24
2006-10-24
Wax, Robert A. (Department: 1653)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Reexamination Certificate
active
07125961
ABSTRACT:
The acid-labile sub-unit (ALS) of insulin like growth factor binding protein complex in biologically pure form is described.ALS has a molecular weight between 80–115 kd as determined by SDS polyacrylamide gel electrophoresis, run under reducing conditions; and a partial N-terminal amino acid sequence as follows:Gly AspProGlyThrProGlyGluAlaGluGlyProAlaCysProAlaAlaCys-Alawherein the first amino acid may be Gly or Ala.Also described are methods of producing ALS, compositions containing the in-vivo IGF protein complex, methods of detecting ALS in body fluids, recombinant nucleic acid sequences encoding ALS, and expression vectors and host cells containing such nucleic acid sequences.
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Bozicevic Field & Francis LLP
Central Sydney Area Health Service
Wax Robert A.
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