Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-06-14
2005-06-14
Wax, Robert A. (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S002600, C514S021800, C530S350000
Reexamination Certificate
active
06906034
ABSTRACT:
The acid-labile sub-unit (ALS) of insulin like growth factor binding protein complex in biologically pure form is described.ALS has a molecular weight between 80-115 kd as determined by SDS polyacrylamide gel electrophoresis, run under reducing conditions; and a partial N-terminal amino acid sequence as follows:GlyAspProGlyThrProGlyGluAlaGluGlyProAlaCysProAlaAlaCysAlawherein the first amino acid may be Gly or Ala.Also described are methods of producing ALS, compositions containing the in-vivo IGF protein complex, methods of detecting ALS in body fluids, recombinant nucleic acid sequences encoding ALS, and expression vectors and host cells containing such nucleic acid sequences.
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Dorsey & Whitney LLP
Genentech Inc.
Trecartin Richard F.
Wax Robert A.
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