Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Albumin
Patent
1991-12-31
1994-04-26
Wityshyn, Michael G.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Albumin
549253, 549332, 549264, 5303919, 530405, 530409, 536 64, 536 221, A61K 3514, C07K 306
Patent
active
053068092
ABSTRACT:
This invention relates to the field of immune therapy of cancer, more specifically to immunoconjugates of a cytotoxic moiety with a targeting moiety, more specifically to immunoconjugates of antibodies or fragments or functional derivatives of antibodies coupled to a cytotoxic substance such as drugs, toxins or radioisotopes. It especially relates to the release of substances bound to a targeting moiety through the use of acid-cleavable linker molecules.
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patent: 4631190 (1986-12-01), Shen et al.
patent: 4997913 (1991-03-01), Hellstrom et al.
patent: 5140013 (1992-08-01), Gaudreault et al.
Y. Liwschitz, et al., J. Chem. Soc. .COPYRGT.1968, 1843-5.
H. O. House, Modern Synthetic Reactions, pp. 132-133, 156-159. W. A. Benjamin; N.Y., N.Y. (1965).
Boon Petrus J.
Bos Ebo S.
Kaspersen Franciscus M.
Akzo N.V.
Blackstone William M.
Gormley Mary E.
Sayala C.
Wityshyn Michael G.
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