Acid labile immunoconjugate intermediates

Details Acid labile immunoconjugate intermediates Acid labile immunoconjugate intermediates

1994-06-30

1997-03-18

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 71, C07H 19173, C07H 1916, C07H 1708

Patent

active

056124740

ABSTRACT:
Trityl derivatives useful as "linkers" for preparation of imunoconjugates comprising drugs end antibodies are provided. Immunoconjugates and processes for their preparation and use are also provided. This invention also provides for prodrugs comprising a substituted trityl group conjugated with a drug of choice as well as methods of using the imunoconjugates and prodrugs of this invention.

REFERENCES:
patent: 3462414 (1969-08-01), Wechter et al.
patent: 4376765 (1983-03-01), Trouet et al.
patent: 4569789 (1986-02-01), Blattler et al.
patent: 5084560 (1992-01-01), Hellstrom et al.

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