Acid inhibitor of bacterial origin

Details Acid inhibitor of bacterial origin Acid inhibitor of bacterial origin

1990-10-10

1993-08-10

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424520, 530825, 514 2, 514926, 435822, A61K 3702, A61K 3574, C12N 120, C07K 1504

Patent

active

052349101

ABSTRACT:
An acid inhibitor of bacterial origin which is effective in inhibiting acid secretion from gastric parietal cells; a method of producing this acid inhibitor; a method of administering the acid inhibitor to reduce acid secretion by parietal cells; and a therapeutic composition, which includes the acid inhibitor, for use in the method. In particular, the invention relates to a protein produced by gastric Spirilla, such as Helicobacter pylori (H. pylori), which is effective in inhibiting acid secretion by parietal cells and, thus, can be used in the treatment of peptic ulcer disease and other conditions of the gastroduodenal tract in which there is a tendency for ulceration.

REFERENCES:
patent: 4882271 (1989-11-01), Evans et al.
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Hill et al, Biol. Abstracts, vol. 85:80064 (1987).
Cave, D. R. and M. Vargas, Supplement to Gastroenterology, 96:A79 (May 1989 Abstract).
Janik, D. S. and D. R. Cave, Gastroduodenal Disease and Campylobacter Pylori, University of Virginia Conference (May 10-12, 1989), Abstract.
Cave, D. R. and M. Vargas, The Lancet, Jul. 22, 1989, pp. 187-189.
Barthel, J. S. et al., Arch. Intern. Med., 148:1149-1151 (1988).
Morris, A. and G. Nicholson, Am J. Gastroenterol., 82:192-199 (1987).
Blaser, M. T., Gastroenterology, 93:371-383 (1987).
Newell, D. G. et al., J. Med. Microbiol., 27:41-44 (1988).
Lee, A. et al., Infect. Immun., 56:2843-2850 (1988).
Hazell, S. L. and A. Lee, The Lancet, Jul. 5, 1986, pp. 15-17.
Henry, G. A. et al., Am. J. Vet. Res., 48:831-836 (1987).
Kawano, S. et al., Gastroenterology, 96:A252 (1989).
King, William and Cave, David R., Abstract P-38 In: Enfermedades Digestivas, Gastroduodenal Pathology and Helicobacter Pylori, Third Workshop of the European Helicobacter pylori Study Group (Supplement I):25 (Nov. 1990).

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