Acid-cleavable compound

Details Acid-cleavable compound Acid-cleavable compound

1985-05-13

1986-10-21

Kight, John

Drug, bio-affecting and body treating compositions

Lymphokine

424 86, 424 87, 435174, 435177, 435181, 514 2, 514 3, 530300, 530322, C07D51900, C07D52100

Patent

active

046184929

ABSTRACT:
Amino-sulfhydryl cross-linking reagents that are cleavable under mildly acidic conditions are disclosed. Also disclosed are methods of making the cross-linkers, as well as methods of using the cross-linkers, e.g., to deliver a biologically active substance across the membranes of selected cells in a heterogeneous cell population; once inside the cell the active substance is released, intact, by the transient, mild acidity of certain cell structure. Finally, a method of characterizing complex multi-chain protein structures is disclosed.

REFERENCES:
patent: 4429008 (1984-01-01), Martin et al.
Carlsson et al, Biochem. J., (1978), vol. 173, pp. 723-737, "Protein Thiolation and Reversible Protein-Protein Conjugation".
Cleland, W. W. (1964) Bioch. 3:480.
Shen and Ryser (1981) Biochem. and Biophys. Res. Commun. 102(3):1048-1054.

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