Acid-cleavable compound

Details Acid-cleavable compound Acid-cleavable compound

1986-09-17

1988-08-16

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Lymphokine

424 86, 424 87, 424 88, 435174, 435177, 435181, 514 2, 514 3, 530300, 530350, C07D51900, C07D52100

Patent

active

047643684

ABSTRACT:
Heterobifunctional reagents that are cleavable under mildly acidic conditions are disclosed. The reagents include an acid cleavable cyclohexene-1,2,-dicarboxylic acid monoamide group. Also disclosed are methods of making the cross-linkers, as well as methods of using the cross-linkers, e.g., to deliver a biologically active substance across the membranes of selected cells in a heterogeneous cell population; once inside the cell the active substance is released, intact, by the transient, mild acidity of certain cell structures. Finally, a method of characterizing complex multi-chain protein structures is disclosed.

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