Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1984-08-29
1985-09-17
Foelak, Morton
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548400, 548517, 548525, 548541, C07D51900, C07D52100
Patent
active
045422257
ABSTRACT:
Amino-sulfhydryl cross-linking reagents that are cleavable under mildly acidic conditions are disclosed. Also disclosed are methods of making the cross-linkers, as well as methods of using the cross-linkers, e.g., to deliver a biologically active substance across the membranes of selected cells in a heterogeneous cell population; once inside the cell the active substance is released, intact, by the transient, mild acidity of certain cell structures. Finally, a method of characterizing complex multi-chain protein structures is disclosed.
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Blattler Walter A.
Lambert John M.
Senter Peter D.
Dana-Farber Cancer Institute Inc.
Foelak Morton
Nutter Nathan M.
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