Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-d

Details Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-d Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-d

1986-06-13

1989-07-04

Fan, Jane T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514457, 549282, 549285, C07D31108, A61K 3137

Patent

active

048451215

ABSTRACT:
The present invention relates to novel benzopyranone aci-reductone compounds of the formula I wherein X and Y are selected from the group comprising H (except that X and Y are not both H, unless otherwise indicated) Cl or other halogen, OH, a straight or branched C.sub.1 -C.sub.6 alkyl or alkoxy group or phenyl or phenyloxy groups, such as, for example a phenyl or a tertiary butyl group. The invention also provides for compounds of the general formula I wherein X, Y=OCH.sub.2 O. ##STR1## The compounds of the invention are useful in the treatment or prevention of thromboembolic disorders.

REFERENCES:
patent: 3585214 (1971-06-01), Boschetti et al.
Witiak et al., J. Med. Chem., 25:90 (1982).
Vargaftig et al., J. Biochem. Pharmac., 30:263 (1981).
Ghosh, K. C., J. Indian Chem. Soc., 24:323-326 (1947).
"Synthesis of Aci-Reductones as a New Class of Potential Hypolipidemic Agents", Kim et al., 18th Graduate Student Meeting in Medicinal Chemistry, Purdue University, Jun. 16-18, 1985.
"Synthesis of Aci-Reductones as a New Class of Potential Hypolipidemic Agents", Kim et al., Biomedical High Technology, 1985 Conference, Ohio State University, Nov. 13-15, 1985.
Antiplatelet Actions of Cyclic and Aci-Reductone Analogs of Clofibric Acid, Romstedt et al., The Pharmacologist, 24, 214 (Jul. 31, 1985).

Affiliated with

Also associated with

Rating

Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-d does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-d, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Aci-reductone compounds belonging to the 6,7-disubstituted-3,4-d will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-852797