Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Reexamination Certificate
2007-04-17
2007-04-17
Chan, Christina (Department: 1644)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
C424S141100, C530S388100
Reexamination Certificate
active
10471475
ABSTRACT:
Anti-acetyllysine monoclonal antibody capable of recognizing Nε-acetyllysine regardless of the types of the adjacent amino acids. Namely, a monoclonal antibody having a light chain comprising a constant region having the amino acid sequence represented by SEQ ID NO:1 and a variable region having the amino acid sequence represented by SEQ ID NO:2 or an amino acid sequence derived from this amino acid sequence by deletion, substitution or addition of one to several amino acids, and a heavy chain comprising a constant region having the amino acid sequence represented by SEQ ID NO:3 and a variable region having the amino acid sequence represented by SEQ ID NO:4 or an amino acid sequence derived from this amino acid sequence by deletion, substitution or addition of one to several amino acids, and being capable of recognizing Nε-acetyllysine in a protein regardless of the types of the adjacent amino acids, i.e., being capable of accepting adjacent amino acids over a broad range; and a process for producing this monoclonal antibody characterized by using a chemically acetylated protein as an antigen.
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White, et al. Preparation of Site-Specific Antibodies to Acetylated Histones.Methods,vol. 19, No. 3, pp. 417-424 (1999).
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Y. Komatsu et al., “Journal of Immunological Methods”, vol. 272, No. 1-2, pp. 161-175 (2003).
Komatsu Yasuhiko
Yoshida Minoru
Chan Christina
Corless Peter F.
Edwards Angell Palmer & & Dodge LLP
Japan Science and Technology Corporation
Kim Yunsoo
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