Acetylenic phenoxypropanol derivatives and pharmaceutical compos

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

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26050117, 514522, 514546, 514605, 514618, 514619, 514620, 514630, 514650, 514652, 549551, 549553, 549556, 549557, 549559, 549560, 558413, 558414, 558422, 560138, 560250, 560251, 564 99, 564162, 564165, 564167, 564220, 564337, 564338, 564349, 564350, 564351, A61K 31275, A61K 31135, C07C 9508, C07C12160

Patent

active

046525840

ABSTRACT:
Phenoxypropanol derivatives having a 2-acetylenic moiety on the phenyl group thereof of the following formula (I): ##STR1## and their use as anti-hypertensives, e.g. in man. Also part of the invention are pharmaceutical compositions and intermediates used in the synthesis.

REFERENCES:
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patent: 3914432 (1975-10-01), Koppe et al.
patent: 3959338 (1976-05-01), Koppe et al.
patent: 4010158 (1977-03-01), Koppe et al.
patent: 4412856 (1983-11-01), Brunner et al.
Michael T. Cox, et al., Journal of Medicinal Chemistry, 1978, vol. 21, No. 2, pp. 182-188.
V. Machacek, et al., Coll. Czechoslov. Chem. Commun., vol. 37, 3073, (1972).
Kenkichi Sonogashira, et al., Tetrahedron Letters, No. 50, pp. 4467-4470, (1975).
R. D. Stephens, et al., Journal of Organic Chemistry 28, pp. 3313-3315, (1963).

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