Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-04-04
2006-04-04
Shameem, Golam M. M. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S106000, C544S162000, C546S184000, C548S566000, C564S305000, C514S231200
Reexamination Certificate
active
07022703
ABSTRACT:
This invention is directed to acetylenic compounds as inhibitors of a nicotinamide adenine dinucleotide oxidase hydride donor useful in treating or ameliorating a reactive oxygen species mediated inflammatory disorder.
REFERENCES:
patent: 6239077 (2001-05-01), Andoh et al.
patent: 0146271 (1985-06-01), None
patent: 0171209 (1986-02-01), None
patent: 0551662 (1993-07-01), None
patent: WO 9504277 (1995-02-01), None
patent: WO 0232435 (2002-04-01), None
Biemond, P. et al., “Superoxide production by polymorphonuclear leucocytes iln rheumatoid arthritis and osteoarthritis: in vivo inhibition by the antirheumatic drug piroxicam due to interference with the activation of the NADPH-oxidase.”Annals of the Rheumatic Disease, 1986, pp. 249-255.
Gould, P.L. et al., “Salt selection for basic drugs,”Intl. J. Pharmaceutics, 1986, pp. 201-217.
Miesel, R. et al., “Antiinflammatory Effects of NADPH Oxidase Inhibitors,”Inflammation, 1995, pp. 347-362, vol. 19.
Miesel, R. et al., “Suppression of Inflammatory Athritis by Siimultaneous Inhibition of Nitric Oxide Synthase and NADPH Oxidase.”Free Radical Biology&Medicine, 1996, pp. 75-81, vol. 20, No. 1.
Hancock, B. C., Characteristics and Significance of the Amorphous State in Pharmaceutical Systems,J. Pharm. Sciences, 1997, pp. 1-12, vol. 86, No. 1.
Bianca, V.D. et al., “β-Amyloid Activates the O Forming NADPH Oxidase in Microglia Monocytes, and Neutrophils,”J. Bio. Chem., 1999, pp. 15493-15499, vol. 274, No. 22.
Begley, T.P. et al., “The Biosynthesis of Nicotinamide Adenine Dinucleotides in Bacteria,”Vitamins&Hormones, 2001, pp. 103-119, vol. 61.
PCT International Search Report dated Jul. 24, 2002 for PCT Appln. No. PCT/US 03/23140 which relates to U.S. Appl. No. 10/626,155.
Beers Scott
Malloy Elizabeth A.
Wachter Michael P.
Dodd Thomas
Janssen Pharmaceutica N.V.
Shameem Golam M. M.
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