Acetylenes disubstituted with a phenyl group and a heterobicycli

Details Acetylenes disubstituted with a phenyl group and a heterobicycli Acetylenes disubstituted with a phenyl group and a heterobicycli

1987-03-26

1989-03-07

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514432, 514456, 546152, 549 23, 549348, 549407, C07D21514, C07D31158, A61K 31335, A61K 3147

Patent

active

048108049

ABSTRACT:
Retinoid-like activity is exhibited by compounds of the formula ##STR1## where X is S, O or NR.sub.1 where R.sub.1 is hydrogen or lower alkyl; n is 0-5; R is H or lower alkyl and A is H, --COOH or a pharmaceutically acceptable salt, ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative thereof, or --CHO or an acetal derivative thereof, or --COR.sub.2 or a ketal derivative thereof where R.sub.2 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4; or a pharmaceutically acceptable salt.

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