Acetylenes disubstituted with a phenyl group and a 2-substituted

Details Acetylenes disubstituted with a phenyl group and a 2-substituted Acetylenes disubstituted with a phenyl group and a 2-substituted

1991-08-26

1992-11-10

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549347, 549374, 549407, C07D31120, C07D33506

Patent

active

051625466

ABSTRACT:
Retinold-like activity is exhibited by compounds of the formula ##STR1## where X is S, O; R.sub.1, R.sub.2 and R.sub.3 are hydrogen or lower alkyl; R.sub.4 and R.sub.5 are hydrogen or lower alkyl with the proviso that R.sub.4 and R.sub.5 cannot both be hydrogen, R.sub.6 is hydrogen, lower alkyl, lower alkenyl, lower cycloalkyl or halogen; n is 0-5, and B is H, --COOH or a pharmaceutically acceptable salt, ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative, or --CHO or an acetal derivative, or --COR.sub.1 or a ketal derivative where R.sub.1 l is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4, or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4096341 (1978-06-01), Frazer
patent: 4695649 (1987-09-01), Magami et al.
patent: 4739098 (1988-04-01), Chandraratna
patent: 4740519 (1988-04-01), Shroot et al.
patent: 4810804 (1989-05-01), Chandraratna
patent: 4826969 (1989-05-01), Maignan et al.
patent: 4855360 (1989-08-01), Chatterjee et al.
patent: 4895864 (1990-01-01), Chandraratna
patent: 4980369 (1990-12-01), Chandraratna
patent: 4992468 (1991-02-01), Chandraratna
patent: 5006550 (1991-04-01), Chandraratna
patent: 5013744 (1991-05-01), Chandraratna
patent: 5015658 (1991-05-01), Chandraratna
patent: 5023341 (1991-06-01), Chandraratna
patent: 5045551 (1991-09-01), Chandraratna
patent: 5053523 (1991-10-01), Chandraratna
Kagechika et al. J. Med. Chem. 1988 31 2182-2192.
Shudo, et al. Chem. Pharm. Bull. 33:404-407 (1985).
Sporn, et al. J. Amer. Acad. Derm. 15:756-764 (1986).
Takahashi, et al. Synthesis 1980:627-30.
Negishi, et al. J. Org. Chem. 45(12) 1980 2326-28.
King, et al. J. Org. Chem. 43(2) 1978 358-360.
Davis, et al. J. Organomettalic. CHem. 387(1990) 381-390.

Affiliated with

Also associated with

Rating

Acetylenes disubstituted with a phenyl group and a 2-substituted does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Acetylenes disubstituted with a phenyl group and a 2-substituted, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acetylenes disubstituted with a phenyl group and a 2-substituted will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2295136