Acetylenes disubstituted with a phenyl group and a 2-substituted

Details Acetylenes disubstituted with a phenyl group and a 2-substituted Acetylenes disubstituted with a phenyl group and a 2-substituted

1989-09-19

1990-12-25

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514456, 549 23, 549407, C07D33506, C07D31104, A61K 3138, A61K 3135

Patent

active

049803697

ABSTRACT:
Retinoid-like activity is exhibited by compounds of the formula ##STR1## where X is S, O; R.sub.1, R.sub.2 and R.sub.3 are hydrogen or lower alkyl; R.sub.4 and R.sub.5 are hydrogen or lower alkyl with the proviso that R.sub.4 and R.sub.5 cannot both be hydrogen, R.sub.6 is hydrogen, lower alkyl, lower alkenyl, lower cycloalkyl or halogen; n is 0-5, and B is H, --COOH or a pharmaceutically acceptable salt, ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative, or --CHO or an acetal derivative, or --COR.sub.1 or a ketal derivative where R.sub.1 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4, or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4739098 (1988-04-01), Chandraratna
patent: 4810804 (1989-03-01), Chandraratna
The Merck Index, 11th Ed., (Rahway, N.J., Merck and Co. Inc. 1989) Compound No. 2257.
Naylor, et al., JACS 53, 1931, pp. 4114-4119.
Frey, et al., DE 3,433,946 Chemical Abstracts, vol. 105, 1986, Abstract 153320r (Equivalent to EP 176034).

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