Acetylenes disubstituted with a heteroaromatic group and a tetra

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514255, 514269, 514277, 514354, 514355, 514356, 514438, 514448, 514467, 514471, 514461, 544224, 544242, 544335, 544336, 544386, 544389, 544398, 544403, C07D23926, C07D23928, C07D23708, C07D23306, C07D24112, A61K 31415

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active

054666902

ABSTRACT:
Retinoid-like activity is exhibited by compounds of the formula ##STR1## where R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, --COOH or an ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative thereof, or --CHO or an acetal derivative thereof, or --COR.sub.1 or a ketal derivative thereof where R.sub.1 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4; or a pharmaceutically acceptable salt thereof.

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