Acetylenes disubstituted with a heteroaromatic group and a tetra

Details Acetylenes disubstituted with a heteroaromatic group and a tetra Acetylenes disubstituted with a heteroaromatic group and a tetra

1987-03-13

1992-09-22

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514247, 514255, 514269, 514277, 514354, 514355, 514438, 514448, 514461, 514471, 546337, 546340, 546342, 546344, 546348, 544224, 544242, 544335, 544336, 544406, 544410, 549 70, 549 71, 549 72, 549 78, 549 80, 549483, 549484, 549486, 549487, 549497, 549506, A61K 31455, C07D21330

Patent

active

051497050

ABSTRACT:
Retinoid-like activity is exhibited by compounds of the formula ##STR1## where R is hydrogen or lower alkyl; A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl or pyrazinyl; n is 0-5; and B is H, --COOH or an ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative thereof, or --CHO or an acetal derivative thereof, or --COR.sub.1 or a ketal derivative thereof where R.sub.1 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4; or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4269848 (1981-05-01), Bayssat et al.
Dawson et al. J. Med. Chem., 27:1516-1531 (1984).
Dawson et al J. Med. Chem, 26:1282-1293 (1983).

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