Acetylenes disubstituted with a heteroaromatic group and a 2-sub

Details Acetylenes disubstituted with a heteroaromatic group and a 2-sub Acetylenes disubstituted with a heteroaromatic group and a 2-sub

1989-09-19

1991-09-03

Kilby Scalzo, Catherine S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514852, 514861, 514863, 546269, 546274, A61K 3144, C07D40104

Patent

active

050455516

ABSTRACT:
Retinoid-like activity is exhibited by compounds of the formula ##STR1## where X is S, O or NR'; where R' is hydrogen or lower alkyl; R.sub.1, R.sub.2 and R.sub.3 are hydrogen or lower alkyl; R.sub.4 and R.sub.5 are hydrogen or lower alkyl with the proviso that R.sub.4 and R.sub.5 cannot both be hydrogen, A is pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl or oxazolyl; n is 0-5, and B is H, --COOH or a pharmaceutically acceptable salt, ester or amide thereof, --CH.sub.2 OH or an ether or ester derivative, or --CHO or an acetal derivative, or --COR.sub.1 or a ketal derivative where R.sub.1 is --(CH.sub.2).sub.m CH.sub.3 where m is 0-4, or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 3704323 (1972-11-01), Krapcho
patent: 3719710 (1973-03-01), Thomas et al.
patent: 4210655 (1980-07-01), Schenker et al.
patent: 4540789 (1985-09-01), Goldmann et al.
patent: 4684661 (1987-08-01), Stuetz

Affiliated with

Also associated with

Rating

Acetylenes disubstituted with a heteroaromatic group and a 2-sub does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Acetylenes disubstituted with a heteroaromatic group and a 2-sub, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acetylenes disubstituted with a heteroaromatic group and a 2-sub will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1009612