Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1996-02-27
1997-01-07
Powers, Fiona T.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546316, 546323, 546326, 549 71, 549 72, 549484, 549486, 549487, C07D21355, C07D30746, C07D33322
Patent
active
055918581
ABSTRACT:
Compounds of the formula ##STR1## wherein the symbols R.sub.1, R.sub.2, R.sub.3, R.sub.19, Y, A, B, m and o have the meaning described in the specification have retinoid like biological activity.
REFERENCES:
patent: 4096341 (1978-06-01), Frazer
patent: 4326055 (1982-07-01), Loeliger
patent: 4391731 (1983-07-01), Boller et al.
patent: 4695649 (1987-09-01), Magami et al.
patent: 4723028 (1988-02-01), Shudo
patent: 4739098 (1988-04-01), Chandraratna
patent: 4740519 (1988-04-01), Shroot et al.
patent: 4810804 (1989-03-01), Chandraratna
patent: 4826969 (1989-05-01), Maignan et al.
patent: 4826984 (1989-05-01), Berlin et al.
patent: 4855320 (1989-08-01), Chatterjee et al.
patent: 4895868 (1990-01-01), Chandraratna
patent: 4927947 (1990-05-01), Chandraratna
patent: 4980369 (1990-12-01), Chandraratna
patent: 4992468 (1991-02-01), Chandraratna
patent: 5006550 (1991-04-01), Chandraratna
patent: 5013744 (1991-04-01), Chandraratna
patent: 5015658 (1991-05-01), Chandraratna
patent: 5023341 (1991-06-01), Chandraratna
patent: 5037825 (1991-08-01), Klaus et al.
patent: 5045551 (1991-09-01), Chandraratna
patent: 5053523 (1991-10-01), Chandraratna
patent: 5068252 (1991-11-01), Chandraratna
patent: 5089509 (1992-02-01), Chandraratna
patent: 5130335 (1992-07-01), Chandraratna
patent: 5134159 (1992-07-01), Chandraratna
patent: 5162546 (1992-11-01), Chandrartna
patent: 5175185 (1992-12-01), Chandraratna
patent: 5183827 (1993-02-01), Chandraratna
patent: 5202471 (1993-04-01), Chandraratna
patent: 5231113 (1993-07-01), Chandraratna
patent: 5234926 (1993-08-01), Chandraratna
patent: 5248777 (1993-09-01), Chandraratna
patent: 5264456 (1993-11-01), Chandraratna
patent: 5264578 (1993-11-01), Chandraratna
patent: 5272156 (1993-12-01), Chandraratna
patent: 5278318 (1994-01-01), Chandraratna
patent: 5324744 (1994-06-01), Chandraratna
patent: 5324840 (1994-06-01), Chandraratna
patent: 5326898 (1994-07-01), Chandraratna
patent: 5344995 (1994-09-01), Chandraratna
patent: 5346895 (1994-09-01), Chandraratna
patent: 5346915 (1994-09-01), Chandraratna
patent: 5348972 (1994-09-01), Chandraratna
patent: 5348975 (1994-09-01), Chandraratna
patent: 5349105 (1994-09-01), Chandraratna
patent: 5354752 (1994-10-01), Chandraratna
patent: 5354776 (1994-10-01), Chandraratna
patent: 5380877 (1995-10-01), Chandraratna
patent: 5391753 (1995-02-01), Chandraratna
patent: 5399561 (1995-03-01), Chandraratna
patent: 5399586 (1995-03-01), Davies et al.
patent: 5407937 (1995-04-01), Chandraratna
patent: 5414007 (1995-05-01), Chandraratna
patent: 5426118 (1995-06-01), Chandraratna
patent: 5434173 (1995-07-01), Chandraratna
patent: 5489584 (1996-02-01), Vuligonda et al.
A General Synthesis of Terminal and Internal Arylalkynes by the Palladium-Catalyzed Reaction of Alkynylzinc Reagents with Aryl Halides, Anthony O. King and Ei-ichi Negishi, J. Org. Chem. 43, No. 2, (1978), 358-360.
Conversion of Methyl Ketones into Terminal Acetylenes and (E)-Trisubstituted Olefins of Terpenoid Origin, Ei-ichi, Anthony O. King and William L Klima, J. Org. Chem., 45, No. 12, (1980), 2526-2528.
Sporn et al., J. Amer. Acad. Derm., 15:756-764 (1986).
A Convienent Synthesis of Ethynylarenes and Diethynylarenes, S. Takahashi, Y. Kuroyama, K. Sonogashira, N. Hagihara, Synthesis (1980) 627-630.
Shudo et al., Chem. Phar. Bull, 33, 404-407, (1985).
Kagechika et al., J. Med. Chem, 31, 2182-2192, (1988).
Chemistry and Biology of Synthetic Retinoids, Marcia I. Dawson and William H. Okamura, CRC Press Inc., (1990), 334-335, 354.
Synthesis of 2,2'-Diacyl-1,1'-biaryls. Regiocontrolled Protection of . . . , Mervic et al., J. Org. Chem., No. 45, 4720-4725 (1980).
A Dopamine Receptor Model and Its Application in the Design of a New Class of Rigid Pyrrolo[2,3-glisoquinoline Antipsychotics, Gary L. Olsen et al., American Chemical Society, (1981), vol. 24, No. 9, pp. 1026-1031.
6.2.3 Conformational Restriction, Williams et al., Drug Discovery and Development, (1987), The Humana Press, pp. 54-55.
V. Retinoid Structure-Biological Activity Relationships, Chemistry and Biology of Synthetic Retinoids, pp. 324-356, (1980).
Davis et al., J. Organometallic Chem. 387 (1980) 381-390.
Effects of 12-Cis-Retinoic Acid, All-Trans-Retinoic Acid and Acetretin on the Proliferation, Lipid Synthesis and Keratin Expression of Cultured Human Seb o cytes In Vitro, C. C. Zouboulis, The Journal of Investigative Dermatology, vol. 96, No. 5, May 1991.
Organ Maintenance of Human Sebaceous Glands: In Vitro Effects of 12-Cis Retinoic Acid and Testosterone, John Ridden et al, Journal of Cell Science, vol. 95, (1990), pp. 125-136.
Characterization of Human Sebaceous Cells In Vitro, Thomas I. Doran et al., The Journal of Investigative Dermatology, vol. 96, No. 3, pp. 341-348, Mar. 1991.
Di-and Tri-Methoxystyryl Derivatives of Heterocyclic Nitrogen Compounds, Bahner, C. T. et al., Arzneim-Forsch./Drug Res., 31(1), Nr. 3 (1981), 404.
Retinobenzoic Acids. 3. Structure-Activity Relationships of Retinoidal Azobenzene-4-Carboxylic Acids and Stilbene-4-Carboxylic Acids, H. Kagechika et al., Journal of Medicinal Chemistry, (1989), 32, pp. 1098-1108.
Synthesis and Evaluation of Stilbene and Dihydrostilbene Derivatives as Potential Anticancer Agents That Inhibit Tubulin Polymerization, Cushman, Mark et al., J. Med. Chem., (1991), 34, 2579-2588.
Synthesis and Evaluation of New Protein-Tyrosine Kinase Inhibitors. Part 1. Pyridine-Containing Stilbenes and Amides, Cushman, Mark et al., Bioorganic & Medicinal Chemistry Letters, vol. 1, No. 4, pp. 211-214, (1991).
Effects of 13-Cis-Retinoic Acid, All-Trans-Retinoic Acid, and Acitretin on the Proliferation, Lipid Synthesis and Keratin Expression of Cultured Human Sebocytes In Vitro, C. C. Zouboulis, The Journal of Investigative Dermatology, vol. 96, No. 5, May 1991, pp. 792-797.
Organ maintenance of human sebaceous glands: in vitro effects of 13-cis retinoic acid and testosterone, John Ridden, et al., Journal of Cell Science, Vo. 95, 1990, pp. 125-136.
Eyrolles, L. et al. "Retinoid Antagonists: Molecular Design Based on the Ligand Superfamily Concept" Med. Chem. Res (1992) 2:361-367.
Liu, S. S. et al. "Systemic Pharmacokinetics of Acetylenic Retinoids in Rats", Drug Metabolism and Disposition, (1990) 18/6:1071-1077.
Beard Richard L.
Chandraratna Roshantha A.
Duong Tien T.
Johnson Alan T.
Lin Yuan
Allergan
Baran Robert J.
Powers Fiona T.
Szekeres Gabor L.
Voet Martin A.
LandOfFree
Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1765455