Acetylene derivatives having lipoxygenase inhibitory activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

564 52, C07C25906, C07C27318, C07C27564, A61K 3117

Patent

active

054768730

ABSTRACT:
Compounds of the structure ##STR1## where p and q are zero or one, but cannot both be the same, M is a pharmaceutically acceptable cation or a metabolically cleavable group, B is a valence bond or a straight or branched alkylene group, R is alkyl, cycloalkyl or --NR.sup.1 R.sup.2, where R.sup.1 and R.sup.2 are hydrogen, alkyl, cycloalkyl or alkanoyl, and A is optionally substituted carbocyclic aryl, furyl, benzo[b]furyl, thienyl, or benzo[b]thienyl are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

REFERENCES:
patent: 4604407 (1986-08-01), Haslanger et al.
patent: 4608390 (1986-08-01), Summers, Jr.
patent: 4822809 (1989-04-01), Summers et al.
patent: 4980362 (1990-12-01), Carceller et al.
patent: 5037853 (1991-08-01), Brooks et al.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Acetylene derivatives having lipoxygenase inhibitory activity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Acetylene derivatives having lipoxygenase inhibitory activity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acetylene derivatives having lipoxygenase inhibitory activity will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-992346

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.