Acetylene compounds and pharmaceutical compositions and methods

Details Acetylene compounds and pharmaceutical compositions and methods Acetylene compounds and pharmaceutical compositions and methods

1992-10-21

1993-09-28

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548510, A61K 31405, C07D20908

Patent

active

052486931

ABSTRACT:
The invention relates to compounds of formula I ##STR1## wherein R is hydrogen or C.sub.1 -C.sub.7 alkyl, or wherein R is the structural element-alk-R.sub.1 in which alk is C.sub.1 -C.sub.7 alkylene, C.sub.2 -C.sub.7 alkylidene or C.sub.3 -C.sub.6 cycloalkylidene and R.sub.1 is hydroxy, C.sub.1 -C.sub.7 alkoxy, phenyl-C.sub.1 -C.sub.7 alkoxy or C.sub.2 -C.sub.7 alkanoyloxy;
in free form or in the form of a salt; processes for their preparation, their use, and also pharmaceutical compositions comprising a compound of formula I in free form or in the form of a pharmaceutically acceptable salt.

REFERENCES:
patent: 4859692 (1989-08-01), Bernstein et al.
patent: 4918094 (1990-04-01), Bernstein et al.
patent: 5096917 (1992-03-01), Sallmann et al.

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