Acetylcholinesterase dual inhibitors

Details Acetylcholinesterase dual inhibitors Acetylcholinesterase dual inhibitors

2011-03-22

2011-03-22

Desai, Rita J (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S105000, C514S290000

Reexamination Certificate

active

07910739

ABSTRACT:
The invention provides compounds of formula:which have a tacrine moiety connected to an heterocyclic moiety through a linker. Through careful selection of the substituents and the linker, the activity and selectivity towards acetylcholinesterase can be modulated. The compounds show potent AChE inhibition activities together with modifications in the β-amyloid aggregation properties by binding simultaneously to the catalytic and peripheral AChE sites. They are useful in the treatment of AChE mediated diseases, such as the Alzheimer's disease.

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