Acetylation process for nucleoside compounds

Details Acetylation process for nucleoside compounds Acetylation process for nucleoside compounds

1975-02-24

1977-05-10

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 22, 536 24, 536 26, C07H 1908

Patent

active

040229637

ABSTRACT:
A method of acetylation of all the hydroxyl groups in the sugar portion of nucleosides which comprises adding acetic acid to a nucleoside to be acetylated in a vessel provided with a reflux condenser, and heating the mixture in the absence of a catalyst until refluxing begins, adding an excess over the stoichiometric amount of acetic anhydride. Continued heating of the mixture is maintained until the reaction is complete and is followed by stripping off acetic acid and any excess acetic anhydride, and the recovery of the acetylated nucleoside product.

REFERENCES:
patent: 3155646 (1964-11-01), Hunter
patent: 3309359 (1967-03-01), Duschinsky et al.
patent: 3817978 (1974-06-01), Jenkins et al.

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