Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2007-07-03
2007-07-03
Campell, Bruce (Department: 1648)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007700, C435S007910, C435S325000, C435S007600, C424S233100
Reexamination Certificate
active
10344243
ABSTRACT:
The present invention is based upon the finding that the protein p300 has acetylation activity which is directed to the retinoblastoma tumour suppressor protein pRb by the presence in the cell of the adenovirus E1A protein. This represents a target for modulators of the cell cycle, to which end the invention provides an assay for a modulator of acetylation of pRb by p300, which comprises: a) bringing into contact a p300 protein a pRb protein and a putative modulator compound under conditions where the p300 protein, in the absence of said modulator is capable of acetylating the pRb protein; b) providing conditions for acetylation of said pRb protein; and c) measuring the degree of inhibition of acetylation caused by said modulator compound.
REFERENCES:
patent: 1 050 581 (2000-08-01), None
patent: WO 99/36532 (1999-07-01), None
Morris et al. Nature cell Biology 2000, vol. 2, pp. 232-239.
Heidi et al. J. Virol. 1995, vol. 69, No. 12, pp. 7917-7924.
Chan et al. Nature cell Biology Jul. 2001, vol. 3, pp. 667-674.
Goodman et al.,CBP/p300 in cell growth, transformation, and development; Genes & Development 14:pp. 1553-1577; XP-002219086.
Chan et al.,Acetylation control of the retinoblastoma tumour-suppression protein; Abstract; Nature Cell Biology, Jul. 2001, 1 page, abstract only.
Chan Ho Man
la Thangue Nicholas Barrie
Campell Bruce
Harness & Dickey & Pierce P.L.C.
Li Bao Qun
The University Court of the University of Glasgow
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