Acetylation of 3-hydroxymethyl cephalosporins

Details Acetylation of 3-hydroxymethyl cephalosporins Acetylation of 3-hydroxymethyl cephalosporins

1992-01-09

1993-06-22

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540215, 540221, 540222, 540228, C07D50104

Patent

active

052217396

ABSTRACT:
Provided is a process for 3' acetylation of 3-hydroxymethylcephalosporins under aqueous conditions.

REFERENCES:
patent: 3445463 (1969-05-01), Heyningen
patent: 3532694 (1970-10-01), Somerfield et al.
Wallingford, et al., Alkyl Carbonates in Synthetic Chemistry, 63 J. Chem. Soc. 2252 (1941).
Abramavitch, et al., A New Method for the Preparation of Ethyl Propionylacetate and Certain Related .beta.-keto esters, 64 J. Chem. Soc. 2271 (1942).
Heyningen, The Chemistry of Cephalosporin Antibiotics, 8 J. Med. Chem., 22 (1965).
Huber, et al., Formation of Desacetylcephalosporin C in Cephalosporin C Fermentation, 16, Applied Microbiology, 1011 (1968).
Heyningen, Cephalosporins, 4 Advanced Drug Research, 27-29 (1968).
Tsushima, et al., A New Route to Semisynthetic Cephalosporins from Deacetylcephalosporin C., 27, Chem. Pharm. Bull. 696 (1979).

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