Acetylated therapeutic procytotoxins

Details Acetylated therapeutic procytotoxins Acetylated therapeutic procytotoxins

2005-05-18

2009-06-23

Canella, Karen A (Department: 1643)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S012200, C530S300000, C530S324000, C530S402000, C530S820000, C530S822000, C530S823000, C530S825000

Reexamination Certificate

active

07550426

ABSTRACT:
A class of procytotoxic agents is characterized by a capability to kill with target cell-specificity. Such an aspect can be a pore-forming protein which has at least one lysine residue, modified by a peptide linkage to an amino acid residue, via the epsilon amino group, and an acetyl group. These agents are useful in treating cancer, especially prostate cancer.

REFERENCES:
patent: 7232800 (2007-06-01), Sun et al.
patent: WO 01/85777 (2001-11-01), None
Warren et al (Cancer Research, 2001, vol. 61, pp. 6783-6787).
Doi et al (Arhives of Biochemistry and Biophysics, 2001, vol. 395, pp. 85-93).
Blondelle et al., (1991)Biochemistry30: 4671-4678.
Dempsey et al., (1991)FEBS Lett.281: 240-244.
Argiolas, A., and Pisano, J., 1985,J. Biol. Chem.260, 1437-1444.
Young et al., (1982)J. Exp. Med.156: 1677.
Lynch et al., (1982) EMBO J 7: 801.
Young & Cohn, (1985)J. Cell Biol.29: 299.
Rosenberg et al., (1989)Molec. Biochem. Parasit.33: 237.
Jansson et al., (1994)Science263: 1440.
Leippe et al., (1994)Proc. Natl. Acad. Sci. USA91: 2602.
Andra et al.,FEBS Letters, 385 (1996), pp. 96-100.
Shai et al., (1996)J. Biol. Chem.271-7305-7308.
Werkmeister et al. (1993),Biochim. Biophys. Acta1157: 50-54.
Horosczewicz et al. (1983),Cancer Res.43: 1809-1818.
Pinto et al. (1999),The Prostate J.1: 15-26.
Wright et al. (1995),Urol. Oncol.1: 18-28.
Lopes et al., (1990),Cancer Res.50: 623-6428.
Troyer et al.,Int. J. Cancer62: 552-558.
Andreu et al., (1983)Proc. Natl. Acad. Sci USA80: 6475-6479.
Andreu et al., (1985)Biochemistry24: 1683-1688.
Fink et al. (Jun. 1989)Int. J. Peptide Protein Res.33: 412-421.
Fink et al., (1989)J. Biol. Chem.264: 6260-6267.
Wallace, B M, Lasker, J S,Science, 260:912-912 (1992).

Affiliated with

Also associated with

Rating

Acetylated therapeutic procytotoxins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Acetylated therapeutic procytotoxins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acetylated therapeutic procytotoxins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4147437