Acetylated low density lipoproteins: a delivery system to phagoc

Details Acetylated low density lipoproteins: a delivery system to phagoc Acetylated low density lipoproteins: a delivery system to phagoc

1988-08-16

1992-01-28

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530359, 530810, C07K 300, C07K 1300, C07K 1500

Patent

active

050844415

ABSTRACT:
Acetylated low density lipoproteins are combined with active and effective lipophilic peptide or other lipophilic immunomodulators, antigens or vaccines to carry the same to macrophage specific targeted receptor mediated endocytosis sites in a living system for treatment of cancer, infection hyperimmune related diseases or deficiences, or to enhance vaccine induction of immunity. Such receptor mediated endocytosis sites are found on macrophages, monocytes and endothelial cells in organs and tissues of the body.
The combination of acetyl-LDL and a lipophilic peptide or related lipophilic immunomodulators, antigens, polynucleotides or vaccines enables delivery of such to be made across vascular barriers by transcytosis. The penetration of endothelial blood-brain, eye or testicular barriers is included in this concept.

REFERENCES:
patent: 4466951 (1984-08-01), Pittman

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