Acetylated amino acids as anti-platelet agents, nutritional...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S546000

Reexamination Certificate

active

08003683

ABSTRACT:
This invention relates to pharmaceutical compounds and nutritional supplements that are acetylated derivatives of naturally occurring amino acids and acetylated derivatives of peptides derived from naturally occurring amino acids containing hydroxyl groups. They are as useful as anti-platelet drugs, and as nutritional supplements.

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patent: 2006/0063827 (2006-03-01), Yu et al.
A. Previero et al., “Specific O-Acylation of Hydroxylamino Acids in Presense of Free Amino Groups.”Biochimica et Biophysica Acta, 7-13; 2 (1972).
Barkdoll A.E. et al., “Syntheses of Tyrosyltyrosyltyrosine and Tyrosyltyrosyltyrosyltyrosine.”Journal of the American Chemical Society, 66, 951-963; 3 (1944).
Sakami et al., “The Investigation of Amino Acid Reactions by Methods of Non-Aqueous Titrimetry.”Journal of Biological Chemistry, 144-203-216; 4 (1942).
Chong Heng et al., “Mechanism of Nasal Absorption of Drugs II: Absorption of L-Tyrosine and the Effect of Structural Modifiction on its Absorption.”Journal of Pharmaceutical Science, 74(12), 1298-1301 (1985).

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