Acetyl CoA carboxylase 2 sequences and methods

Details Acetyl CoA carboxylase 2 sequences and methods Acetyl CoA carboxylase 2 sequences and methods

2007-05-01

2007-05-01

Rao, Manjunath N. (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

C435S006120, C435S325000, C435S069100, C435S183000, C435S320100, C435S252300, C435S023000

Reexamination Certificate

active

11186999

ABSTRACT:
The present invention relates generally to novel nucleotide and amino acid sequences, and more particularly to novel human acetyl CoA carboxylase 2 (ACC2) and rat ACC2 sequences. The sequences provided herein can be expressed in a recombinant format. Methods of isolating the ACC2 sequence are also provided, which can be employed to isolate any ACC sequence. The ACC2 sequences can be employed in therapeutic applications to diagnose or treat a condition associated with ACC2. The invention also relates to the identification of modulators of ACC activity using the recombinant human ACC2 enzyme as the screening target.

REFERENCES:
patent: WO02/079441 (2002-10-01), None
Abu-Elbeiga, et al., “The subcellular localization of acetyl-CoA carboxylase 2”, PNAS, vol. 97(4), pp. 1444-1449 (2000).
Beaty, et al., “Acetyl Coenzyme A Carboxylase”, J. Biol. Chem., vol. 257(2), pp. 924-929 (1982).
Ha, et al., “Cloning of human acetyl-CoA carboxylase-β and its unique features”, PNAS, vol. 93, pp. 11466-11470 (1996).
Tanabe, et al., “[1] Acetyl-CoA Carboxylase from Rat Liver”, Methods Enzymol., vol. 71, pp. 5-16 (1981).
NCBI Entrez Accession No. NM—053922 (gi:16758803), Rubink, et al., Oct. 17, 2005.

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