Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-07-17
2007-07-17
Davis, Zinna N. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S307000, C514S396000, C514S378000, C514S432000, C514S456000, C544S053000, C544S056000, C546S139000, C548S240000, C548S326500
Reexamination Certificate
active
10658959
ABSTRACT:
Disclosed are compounds of the formula:where variables Z, X, R15, R2, R3, and RCare defined herein. Compounds disclosed herein are inhibitors of the beta-secretase enzyme and are therefore useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal.
REFERENCES:
patent: 5362912 (1994-11-01), Sowin et al.
patent: 5387742 (1995-02-01), Cordell
patent: 5612486 (1997-03-01), McConlogue et al.
patent: 5696270 (1997-12-01), Kempf et al.
patent: 5720936 (1998-02-01), Wadsworth et al.
patent: 5766846 (1998-06-01), Schlossmacher et al.
patent: 5811633 (1998-09-01), Wadsworth et al.
patent: 5850003 (1998-12-01), McLonlogue et al.
patent: 5877015 (1999-03-01), Hardy et al.
patent: 5877399 (1999-03-01), Hsiao et al.
patent: 5892052 (1999-04-01), Kempf et al.
patent: 6150416 (2000-11-01), Kick et al.
patent: 6150530 (2000-11-01), Kempf et al.
patent: WO 96/39385 (1996-12-01), None
patent: WO 00/17369 (2000-03-01), None
Hall, et al., A Simple Method for Converting Nitriles to Amides. Hydrolysis with Potassium Hydroxide in tert-Butyl Alcohol;J. Org. Chem., 41, No. 23., 3769-3770 (1976).
Games et al., Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-Amylold precursor protein;Letters to Nature; 373, No. 6514 (1995).
Kang et al., Synthesis of 1,4-diaminocyclitois From L-Serine Methyl Ester;J. Org. Chem. 61, 5528-5531 (1996).
Benedetti, et al., Versatile and Stereoselective Synthesis of Diamino Diol Dipeptide Isosteres, Core Units of Pseudopeptide HIV Protease Inhibitors;J. Org. Chem. 62, 9348-9353 (1997).
Zuccarello, et al.; HIV-1 Protease Inhibitors Based on Acyclic Carbohydrates;J. Org. Chem. 63, 4898-4906 (1998).
Lee, et al.; Development of a New Type of Protease Inhibitors, Efficiacious against FIV and HIV Variants;J. Am. Chem. Soc.; 121, 1145-1155 (121).
Albright and Du; Synthesis of 1,4,5,6-Tetrahydropyrazolo[3,4-d]pyrido[3,2-b]azepine;J. Heterocyclic Chem.; 37, 41-46 (2000).
Ping, et al.; The Study on HCMV Protease Inhibitors (I) Design and Liquid-phase Combinatorial Building Block Synthesis of Peptidomimetic Inhibitors;Chinese Journal of medicinal Chemistry; 11, No. 1, (2001).
Kempf, et al., “Symmetry-Based Inhibitors of HIV Protease. Structure-Activity Studies of Acylated 2,4-Diamino-1,5-diphenyl-3-hydroxypentane and 2,5-Diamino-1,6-diphenylhexane-3,4-diol,”J. Med. Chem., 36, 320-330 (1993).
Baldwin Eric T.
Beck James P.
Hughes Robert
John Varghese
Maillard Michel
Davis Zinna N.
Elan Pharmaceuticals Inc.
McDonnell Boehnen & Hulbert & Berghoff LLP
Pharmacia & Upjohn Company
LandOfFree
Acetyl 2-hydroxy-1, 3-diaminoalkanes does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Acetyl 2-hydroxy-1, 3-diaminoalkanes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acetyl 2-hydroxy-1, 3-diaminoalkanes will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3802629