Acetoxy azetidin-2-one antibiotics via thiazolidine ring cleavag

Details Acetoxy azetidin-2-one antibiotics via thiazolidine ring cleavag Acetoxy azetidin-2-one antibiotics via thiazolidine ring cleavag

1978-11-28

1980-05-20

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

548201, 548188, 2602454, C07D20508

Patent

active

042038960

ABSTRACT:
Monocyclic .beta.-lactam antibiotics of the formula ##STR1## wherein R is amino or acylamino, e.g., phenylacetylamino, phenylglycylamino and 2-[4-(3-amino-3-carboxypropoxy)phenyl]-2-hydroximinoacetylamino; R.sub.1 is H or ester forming group; R.sub.2 is H, --OCH.sub.3, --SCH.sub.3, or --CH.sub.3 ; and R.sub.3 is H or acetoxy; are useful antibacterials for controlling .beta.-lactamase producing gram-negative bacteria and other pathogens. Intermediates useful in the preparation of the antibiotics and a novel process for preparing 4.alpha.-acetoxy substituted azetidin-2-ones are provided.

REFERENCES:
Stoodley et al. JCS Perkins I, (1973) pp.32-35.
Brain et al. J. Chem. Soc., Perkins I, pp. 447-451) (1976).

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