Acetohydroxamic acids

Details Acetohydroxamic acids Acetohydroxamic acids

1978-08-04

1979-05-01

Evans, Joseph E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

2603405R, 2605005H, A61K 31185, C07C 8310, C07D31746

Patent

active

041524586

ABSTRACT:
The invention provides new acetohydroxamic acid derivatives, having interesting properties on the central nervous system, of the formula: R.sub.1 R.sub.2 R.sub.3 C--CO--NHOH, in which R.sub.2 and R.sub.3 are each hydrogen or C.sub.1-6 alkyl, and R.sub.1 is C.sub.1-6 alkyl Z.sub.1 Z.sub.2 N (where Z.sub.1 and Z.sub.2 are each phenyl, substituted phenyl, or cycloalkyl), substituted hydantoinyl, benzhydroxycarboxamido, Z.sub.3 CH.sub.2 -- (where Z.sub.3 =optionally substituted aryl), Z.sub.4 --A-- (where Z.sub.4 is optionally substituted phenyl or naphthyl, and A is --NH--,--N(C.sub.1-4 alkyl)-, --N(C.sub.5-6 cycloalkyl)-, --NHCO--, --N(C.sub.1-4 alkyl)CO--, --N(C.sub.5-6 cycloalkyl)CO--, --CONH--, --CON(C.sub.1-4 alkyl)-, --CON(C.sub.5-6 cycloalkyl)-, --NHCONH--, --(N(C.sub.5 H.sub.6)CONH--, or --(N(substituted phenyl)CONH--, optionally substituted benzimidazolyl, or an optionally substituted tricyclic radical, and their metal and acid addition salts.

REFERENCES:
patent: 2862020 (1958-11-01), Hegedus
patent: 3728380 (1973-04-01), Johnson et al.
Puraczewski et al., "Bulletin de l'Academie Polonaise des Sciences", Serie des Sciences Chemiques, vol. XII, No. 14, 1964, pp. 773-779.

Affiliated with

Also associated with

Rating

Acetohydroxamic acids does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Acetohydroxamic acids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acetohydroxamic acids will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-631960