Acetic acid derivatives and composition containing the same

Details Acetic acid derivatives and composition containing the same Acetic acid derivatives and composition containing the same

1981-03-20

1982-10-26

Raymond, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Allergen or component thereof

42424851, 42424854, 42424857, 424250, 424251, 424258, 424263, 424267, 424274, 424278, 424285, 544145, 544147, 544298, 544318, 544319, 544375, 546141, 546147, 546153, 546174, 546196, 546202, 546269, 546274, 548525, 549 12, 549354, A61K 31335, A61K 3138, C07D31312, C07D33712

Patent

active

043561861

ABSTRACT:
Novel acetic acid derivatives of the formula: ##STR1## wherein X is oxygen or sulfur; R.sub.1 is hydrogen or a lower alkyl; R.sub.2 is hydroxy, an alkoxy, an alkenyloxy, a cycloalkyloxy, an aryloxy, a substituted aryloxy, an aryl-lower alkoxy, a substituted aryl-lower alkoxy, an aryl-lower alkenyloxy, a substituted aryl-lower alkenyloxy, an .omega.-disubstituted amino-lower alkoxy, a lower alkoxycrbonyl-lower alkoxy, a lower alkoxy-lower alkoxy, a hydroxy-lower alkoxy-lower alkoxy, an acyl-lower alkoxy, or a group ##STR2## wherein R.sub.3 is hydrogen, hydroxy, a lower alkyl, an aryl-lower alkyl, a hydroxy-lower alkyl, or a carboxy-lower alkyl, R.sub.4 is hydrogen, a lower alkyl or a hydroxy-lower alkyl, or the R.sub.3 and R.sub.4 may combine together with the nitrogen atom to which they are joined to form a heterocyclic group; and the group --CH(R.sub.1)COR.sub.2 is joined to the carbon atom at 2- or 3-position, and pharmaceutically acceptable salts thereof, processes for their preparation, and pharmaceutical compositions containing these compounds. They have excellent anti-inflammatory, analgesic and antipyretic activities with weak ulcerogenicity in the gastrointestinal tract and toxicity.

REFERENCES:
patent: 4000308 (1976-12-01), Ackrell
patent: 4107322 (1978-08-01), McFadden et al.
Kirby et al., J.C.S. Chem. Comm., 1980, No. 4, pp. 150 and 151.

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