Acetazolamide-related compounds, process for their preparation,

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D28508

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active

050102044

ABSTRACT:
Compounds related to acetazolamide and to its N-methyl derivatives, of the formulae: ##STR1## wherein Y is one of the following groups: ##STR2## R.sub.1 being a straight or branched alkylene or arylalkylene, or a phenylene, and the processes for their preparation; the compounds so obtained are inhibitors of carbonic anhydrase like acetazolamide but, in addition, they are well absorbed topically so that they can be used as drugs for treating glaucoma.

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Tinker et al, J. Pharmacology and Experimental Therapeutics, vol. 218, pp. 600-607, 1981.
Vaughan et al, J. Organic Chemistry, vol. 21, pp. 700-701, 1956.
Chemical Abstracts, vol. 98, No. 4, Mar. 28, 1983, p. 596, Abstract No. 107226D.
Article by P. G. DeBenedetti et al., "A Quantum Chemical QSAR Analysis of Carbonic Anhydrase Inhibito by Heterocyclic Sulfonamides, Sulfonamide Carbonic Anhydrase Inhibitors: Quantum Chemical QSAR".

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