Acetamidobenzamide compounds for neurodegenerative disorders

Details Acetamidobenzamide compounds for neurodegenerative disorders Acetamidobenzamide compounds for neurodegenerative disorders

1997-03-06

1998-05-26

Kumar, Shailendra

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564153, 564155, 564156, A61K 31165, C07C23305, C07C23365

Patent

active

057565481

ABSTRACT:
A group of benzamide compounds are disclosed which are useful for treating neurodegenerative disorders. Methods for making these compounds are provided. These materials are formed into pharmaceutical compositions for oral or intravenous administration to patients suffering from conditions such as Parkinson's disease which can exhibit themselves as progressive loss of central nervous system function. The compounds can arrest or slow the progressive loss of function.

REFERENCES:
patent: 4927928 (1990-05-01), Shroot et al.
patent: 5212203 (1993-05-01), Shroot et al.
patent: 5346691 (1994-09-01), Raspanti et al.
patent: 5472983 (1995-12-01), Flitter et al.
Freter et.al., Liebigs Ann. Chem., 811-820, 1973.
R.W. Hartman et al., Eur. J. Med. Chem. (1994) 29, 807-817.
L.A. Errede, et al., J. Org. Chem. (1977) 42(4) 656-658.
EPO Patent Abstracts of Japan, vol. 7, No. 155, and Derwent Abstract No. 83-52581K (Abstracts of Japanese Publication No. JP 58067657, published Apr. 22, 1983).
EPO Patent Abstracts of Japan, vol. 6, No. 90, and Derwent Abstract No. 82-20427E (Abstracts of Japanese Publication No. JP 57021320, published Feb. 4, 1982).
Chemical Abstract No. 61:13221d (1964) (Abstract 15 of M. Melandri, et al., Bull. Chim. Farm. 103, 475-489).
Chemical Abstract No. 58:4541a (1963) (Abstract of M. Itaya, et al., Yakugaku Zasshi (1962) 82, 634-639).
Banasik et al., "Specific inhibitors of poly(ADP-Ribose) synthase and mono(ADP-ribosyl)transferase" J. Biol. Chem. (1992) 267:1569-1575.
Beal, M.F. in Mitochondrial Dysfunction and Oxidative Damage in Neurodegenerative Diseases, R.G. Landes Publications Austin, TX, (1995) pp. 53-61 and 73-99.
Bishop et al., "Synthesis and in vitro evaluation of 2,3-dimethoxy-5-(fluoroalkyl)-substituted benzamides: high-affinity ligands for CNS dopamine D.sub.2 receptors" J. Med. Chem. (1991) 34:1612-1624.
Burns, R.S., et al., "A Primate Model of Parkinsonism . . . " Proc. Natl. Acad. Sci. USA (1983) 80:4546-4550.
Calne, D.B., "Treatment of Parkinson's Disease" NEJM (Sep. 30, 1993) 329:1021-1027.
El Tayar, et al., "Interaction of neuroleptic drugs with rat striatal D-1 and D-2 dopamine receptors: a quantitative structure--affinity relationship study" Eur. J. Med. Chem. (1988) 23:173-182.
Gerlach, M. et al., "MPTP Mechanisms of Neurotoxicity and the Implications for Parkinson's Disease" European Journal of Pharmacology (1991) 208:273-286.
Heikkila, R.E., et al., "Dopaminergic Neurotoxicity of 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine in Mice" Science (Jun. 29, 1984) 224:1451-1453.
Hogberg et al., "Potential antipsychotic agents. 9. Synthesis and stereoselective dopamine D-2 receptor blockade of a potent class of other side chain congeners" J. Med. Chem. (1991) 34:948-955.
Kato, T., "Reaction of Triethyloxonium Fluoroborate with Acid Amide. III.sup.1) Formation of Quinazoline and 4H-3, 1-Benzoxazin-4-one Derivatives", Chem. Pharm. Bull. (1976) 24, 3:431-436.
Katopodis et al., "Novel substrates and inhibitors of peptidylglycine .alpha.-amidating monooxygenase" Biochemistry (1990) 29:4541-4548.
Langston, J.W., et al., "Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis" Science (Feb. 25, 1983) 219, 979-980.
Marsden, C.D., in "Review Article--Parkinson's Disease" Lancet (Apr. 21, 1990) 948-952.
Mizuno, Y., Mori, H., Kondo, T. "Potential of Neuroprotective Therapy in Parkinson's Disease" CNS Drugs (1994) 1:45-46.
Monkovic et al., "Potential non-dopaminergic gastrointestinal prokinetic agents in the series of substituted benzamides" Eur. J. Med. Chem. (1989) 24:233-240.
Rainnie et al., "Adenosine inhibition of mesopontine cholinergic neurons: implications for EEG arousal" Science (1994) 263:689-690.
Singer, T.P., et al., "Biochemical Events in the Development of Parkinsonism . . . " J. Neurochem. (1987) 1-8.

Affiliated with

Also associated with

Rating

Acetamidobenzamide compounds for neurodegenerative disorders does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Acetamidobenzamide compounds for neurodegenerative disorders, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acetamidobenzamide compounds for neurodegenerative disorders will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1960774