Acetamide derivative having defined particle size

Details Acetamide derivative having defined particle size Acetamide derivative having defined particle size

1994-10-06

1997-04-08

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

424489, A61K 914, A61K 3116

Patent

active

056188455

ABSTRACT:
Pharmaceutical compositions comprising modafinil in the form of particles of defined size. The particle size of modafinil can have a significant effect on the potency and safety profile of the drug.

REFERENCES:
patent: 4002718 (1977-01-01), Gardella et al.
patent: 4122157 (1978-10-01), Huber
patent: 4177290 (1979-12-01), Lafon
patent: 4196188 (1980-04-01), Besins
patent: 4332721 (1982-06-01), Bernini
patent: 4713246 (1987-12-01), Begum et al.
patent: 4880623 (1989-11-01), Piergiorgio et al.
patent: 4895726 (1990-01-01), Curtet et al.
patent: 4927855 (1990-05-01), Lafon
patent: 5021242 (1991-06-01), Romer et al.
patent: 5180745 (1993-01-01), Lafon
patent: 5202129 (1993-04-01), Samejima et al.
patent: 5391576 (1995-02-01), Lafon
Remington's Pharmaceutical Sciences 16th Ed (1980) pp. 1355-1368, 305-306, 1535-1545.
Shepherd Othero Sclerosis 110/Suppl !555-563(1994) Micronized Lenojitrate.
Kondo Biol. Pharm Bull. 16(8):746-800 (1993) HO-221-A Micronized Poorly Solable Drug.
Carlson et al Clin. Ther. 15(5):788-796 (1993) Micronized Glyburide.
Treffel et al Acta Derm. Venerol. 72(1):65-67 (1992) Micronized 5-Methoxypsoralen.
Hargrove et al AM. J. Abstrt. Gynecol. 161(4):948-951 (1989) Micronized Progesterone.
Stock et al Bor. J. Dermatol. 112(4):469-473 (1985) Micronized 5-Methoxypsoralen
McInnes et al. J. Clin Pharmacol 22(8):410-417 Micronized Spironolactone.
Lavharanta et al Arch. Dermatol. Res. 273(1/2) 111-114 (1982) Micronized 8-Methoxypsoralen.
Bastuji H. et al.; "Successful Treatment of Idiopathic Hypersomnia and Narcolepsy with Modafinil"; Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 12:695-700 (1988).
Becue T. et al.; "Confirmation of the Structure of By-Products in the Synthesis of Modafinil by Liquid Chromatography-Mass Spectrometry"; J. Chromatography 557:489-494 (1991).
Drouin J.E. et al.; "Optimization of the Mobile Phase for the Liquid Chromatographic Separation of Modafinil Optical Isomers on a Chiral-AGP Column"; J. Chromatography 605:19-31 (1992).
Duteil J. et al.; "Central .alpha..sub.1 -Adrenergic Stimulation in Relation to the Behavior Stimulating Effect of Modafinil; Studies with Experimental Animals"; European J. Pharmacol. 180:49-58 (1990).
Drugs of the Future; "Modafinil"; 15(2):130-132 (1990).
Fuxe K. et al.; "Evidence for a Protective Action of the Vigilance Promoting Drug Modafinil on the MPTP-Induced Degeneration of the Nigrostriatal Dopamine Neurons in . . . "; Exp. Brain Res. 88:117-130 (1992).
Lyons T.J. et al.; "Modafinil: The Unique Properties of a New Stimulant"; Aviation, Space & Environ. Med. 432-435 (1991).
Milhaud C. et al.; "Effects of Modafinil, An Alpha I Adrenergic Type Psychostimulant on the Sleep of Monkeys"; Psychopharmacology 96:Abstract No. 31.05.09 (1988).
Milhaud C.L. et al.; "Presentation of d'un Nouveau Stimulant:Le CRL-40476"; AGARD Conf. Proc. 415:5-1-5-7 (1987).
Moachon G. et al.; "Simultaneous Determination of Modafinil and its Acid Metabolite by High-Performance Liquid Chromatography in Human Plasma"; J. Chromatography B 654:91-96 (1994).
Roze C. et al.; "Drug CRL 40 028-Induced Inhibition of Pancreatic Secretion in Rats"; Arch Int Pharmacodyn 265:119-127 (1983).
Saletu B. et al.; "Differential Effects of a New Central Adrenergic Agonist-Modafinil-and D-Amphetamine on Sleep and Early Morning Behaviour in Young Healthy Volunteers"; Int J Clin Pharm Res IX(3):183-195 (1989).

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