Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1977-12-30
1978-08-15
Rollins, Alton D.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260296B, 2602948C, 2603407, 260295K, 2603409R, C07D24320, C07D40104, C07D40512, C07D40514
Patent
active
041071590
ABSTRACT:
Compounds of the formula: ##STR1## wherein R.sub.1 is alkyl of 1 to 3 carbon atoms, inclusive; wherein R.sub.2 is hydrogen, methyl or ethyl; wherein R.sub.3 is hydrogen, fluoro, chloro, bromo, nitro and --CF.sub.3 ; and wherein A is phenyl, o-chlorophenyl, o-fluorophenyl, 2,6-difluorophenyl, and 2-pyridyl, are prepared by treating a hydrazino compound of the formula: ##STR2## with a carbonyl compound II: ##STR3## wherein R.sub.1 is defined as above, and R', R" are alkyl of 1 to 3 carbon atoms, inclusive or the group ##STR4## is a cyclic acetal to give a compound of formula III: ##STR5## wherein R.sub.1, R.sub.2, R.sub.3, R', R" and Ar are defined as above, and cyclizing compound III to give the compound IV above.
Compounds III and IV, including the pharmacologically acceptable acid addition salt of these compounds, have sedative, anxiolytic and muscle-relaxing activity and can be used for the treatment of anxieties or muscle strains of mammals, including man.
REFERENCES:
patent: 3864328 (1975-02-01), Fryer et al.
patent: 3946032 (1976-03-01), Allgeier et al.
Berneis Hans L.
Rollins Alton D.
The Upjohn Company
LandOfFree
Acetal hydrazones of 2-hydrazino-3H-1,4-benzodiazepine does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Acetal hydrazones of 2-hydrazino-3H-1,4-benzodiazepine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acetal hydrazones of 2-hydrazino-3H-1,4-benzodiazepine will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1434043