Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-11-22
1997-09-30
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514415, 514466, 514468, 514605, 514608, 514634, A61K 3147, A61K 31405, A61K 3136, A61K 31155
Patent
active
056726082
ABSTRACT:
Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N'"-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.
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Fischer James B.
Goldin Stanley M.
Hu Lain-Yen
Katragadda Subbarao
Knapp Andrew Gannett
Cambridge NeuroScience, Inc.
Cebulak Mary C.
Conlin David G.
Corless Peter F.
Dees Jos,e G.
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