Acenaphthyl substituted guanidines and methods of use thereof

Details Acenaphthyl substituted guanidines and methods of use thereof Acenaphthyl substituted guanidines and methods of use thereof

1995-06-05

1997-03-25

Clardy, S. Mark

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549283, 552 8, 558422, 564237, 564238, 564239, C07C27906, C07C27908, C07C27910, C07C27916

Patent

active

056146302

ABSTRACT:
Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N'"-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use of such neurotransmitter release modulators for the treatment or prevention of pathophysiologic conditions characterized by the release of excessive or inappropriate levels of neurotransmitters. Also disclosed are screening assays for compounds which selectively inhibit glutamate release. Also disclosed are methods of blocking voltage sensitive sodium and calcium channels in mammalian nerve cells.

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