Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Mixing of two or more solid polymers; mixing of solid...
Patent
1988-05-25
1990-02-13
Kight, John
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Mixing of two or more solid polymers; mixing of solid...
525 5424, 530385, 514 6, C08L 8900, C08F 1600, C07G 700
Patent
active
049007807
ABSTRACT:
An acelluar resuscitative fluid, useful as an artificial blood or blood substitute, is prepared from a modified, high molecular weight starch or a tetronic polyol prepared by the interaction of ethylenediamine and ethylene or propylene oxides, which are converted to their aldehyde form. This material is reacted with a stabilized, stroma free hemoglobin, which has been converted to an oxy-acid or diketone. The resulting solution, after purification, can be administered to an animal in the same manner as whole blood. If desired, the solution of the reaction product with the stabilized hemoglobin can be freeze-dried and later reconstituted by the addition of water to provide the administrable fluid.
REFERENCES:
patent: 4336248 (1982-06-01), Bonhard et al.
patent: 4650786 (1987-03-01), Wong
patent: 4698387 (1987-10-01), Schmidt et al.
Cerny et al., "A Hydroxyethyl Starch-Hemoglobin Polymer as a Blood Substitute", Clinical Hemorheology, vol. 2, pp. 355-365, 1982.
Cerny et al., "Mixtures of Whole Blood and Hydroxyethyl Starch-Hemoglobin Polymers", Critical Care Medicine, vol. 11, No. 9, pp. 739-743, 1983.
Cerny et al., "A Blood Substitute from Hydroxyethyl Starch and Hemoglobin", Applied Biochemistry and Biotechnology, vol. 10, pp. 151-153, 1984.
Kight John
Masonic Medical Research Laboratory
Nutter Nathan M.
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