Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-02-28
1995-11-07
Low, Christopher S. F.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
530385, 424529, 424533, 514832, A61K 3714
Patent
active
054648149
ABSTRACT:
A process is disclosed for the preparation of an essentially tetramer-free, essentially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin which comprises separating red blood cell stroma from blood by means of heat treating step to remove stromal contaminants and filtration or centrifugation or both, pyridoxylating, polymerizing, and removing essentially all of the remaining unmodified tetramer.
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Benesch et al. (1975), Hemoglobin covalently bridged across the polyphosphate binding site. Biochem, Biophys. Res. Comm. 63(4):1123-1129.
Moss et al. (1984, Mar.). Hemoglobin solution--from tetramer to polymer. Surgery 95(3):249-255. (abstract).
Sehgal et al. (1983, Mar.-Apr.). Preparation and in vitro characteristics of polymerized pyridoxylated hemoglobin. Transfusion 23(2):158-162. (abstract).
De Woskin Richard E.
Gould Steven A.
Moss Gerald S.
Rosen Arthur L.
Sehgal Hansa
Low Christopher S. F.
Northfield Laboratories, Inc.
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