Acellular pertussis vaccines and methods of preparing thereof

Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification

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530413, 530414, 530415, 530417, 530418, 530419, 530421, 530422, A23J 100, C07K 100

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058772987

ABSTRACT:
A fimbrial agglutinogen preparation is prepared from a bordetella strain, particularly a B. pertussis strain, by a multiple step procedure involving extraction of the fimbrial agglutinogens from cell paste and concentrating and purifying the extracted material. The fimbrial agglutinogen preparation may be used to prepare acellular pertussis vaccines with other pertussis antigens, including pertussis toxin or toxoid thereof, the 69 kDa protein and filamentous hemagglutinin and other Bordetella antigens.

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Fredriksen et al. Proceedings of the 4.sup.th Int'l. Symp. on Pertussis vol. 61, pp. 187-196 (1985).

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