Acellular immunogenic compositions and acellular vaccine...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

Reexamination Certificate

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C424S234100, C424S236100, C424S235100, C424S193100, C424S197110, C424S200100, C530S350000, C435S242000, C435S252300, C435S252310

Reexamination Certificate

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07491404

ABSTRACT:
The invention concerns an acellular immunogenic or vaccine composition for producing antibodies againstBacillus anthraciscomprising a protective antigen (PA) and killed and optionally purified spores, obtained from mutating strains ofBacillus anthracisand their uses.

REFERENCES:
patent: 0 739 981 (1996-10-01), None
XP-000922808, S. Welkos, et al., “Comparative safety and efficacy againstBacillus anthracisof protective antigen and live vaccines in mice”, Microbial Pathogenesis, 1988, vol. 5, No. 3, pp. 127-140.
XP-000215550, P. Turnbull, “Anthrax vaccines: past, present and future”, Guildford Surrey, GB, vol. 9, No. 8, Aug. 1991, pp. 533-539.
A. Stepanov, et al., “Development of novel vaccines against anthrax in man”, Journal of Biotechnology, vol. 44, No. 1, pp. 155-160, Jan. 26, 1996.
XP-000922839, V. Abalakin, et al., “Protective and other biological propeties ofBacillus anthracissoluble antigens”, vol. 35, No. 1, pp. 83-91, 1991.
XP-00214827, I. Kravets, et al., “Mixed anthrax vaccine having improved quality”, Res. Instit., Jul. 1998, Derwent abstract only.
XP-002141826, V. Abalakin, et al., Zhurnal Mikrobiologii, Epidemiologii, Immunologii, No. 5, 1990, pp. 72-75.
C. Pezard, et al., “Protective immunity induced byBacillus anthracistoxin-deficient strains”, Infection and Immunity, vol. 63, No. 4, Apr. 1995, pp. 1369-1372.
B. Ivins, et al., “Immunization studies with attenuated strains ofBacillus anthracis”, Infection and Immunity, vol. 52, No. 2, May 1986, pp. 454-458.
B. Ivins, et al., “Recent advances in the development of an improved human anthrax vaccine”, Eur. J. Epidemiol, vol. 4, No. 1, Mar. 1988, pp. 12-19.

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