Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-02-14
2006-02-14
Wilson, James O. (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S540000, C424S422000, C623S011110, C623S013190, C623S023480, C435S325000
Reexamination Certificate
active
06998418
ABSTRACT:
A method for promoting autogenous ingrowth of damaged or diseased tissue selected from a group consisting of ligaments, tendons, muscle and cartilage, the method comprising a step of surgically repairing the damaged or diseased tissue by attachment of a tissue graft, wherein the tissue graft is formed from a segment of connective tissue protein after an acellularization process, the segment being crosslinked with genipin, its analog or derivatives. The genipin-fixed acellular tissue provides a microenvironment for tissue regeneration adapted for use as a biological implant device due to its low cytotoxicity.
REFERENCES:
patent: 4082507 (1978-04-01), Sawyer
patent: 4806595 (1989-02-01), Noishiki et al.
patent: 5194596 (1993-03-01), Tischer et al.
patent: 5281422 (1994-01-01), Badylak et al.
patent: 5372821 (1994-12-01), Badylak et al.
patent: 5445833 (1995-08-01), Badylak et al.
patent: 5573784 (1996-11-01), Badylak et al.
patent: 5599558 (1997-02-01), Gordinier et al.
patent: 5800537 (1998-09-01), Bell
patent: 5893888 (1999-04-01), Bell
patent: 5929038 (1999-07-01), Chang
patent: 6051750 (2000-04-01), Bell
patent: 6103255 (2000-08-01), Levene et al.
patent: 6162826 (2000-12-01), Moon et al.
patent: 6206931 (2001-03-01), Cook et al.
patent: 6261565 (2001-07-01), Empie et al.
patent: 6262083 (2001-07-01), Moon et al.
patent: 6264992 (2001-07-01), Voytik-Harbin et al.
patent: 6340480 (2002-01-01), Duckett et al.
patent: 6485723 (2002-11-01), Badylak et al.
patent: 6506398 (2003-01-01), Tu et al.
patent: WO 98/19718 (1998-05-01), None
Courtmen et al, J. Biomedical Materials Research, 1994, 28, 655-666.
Malone et al, J. Vasc. Surg, 1984, 1, 181-191.
Sung HW et al., “In Vitro Evaluation of Cytotoxicity of a Naturally Occuring Crosslinking Reagent for Biological Tissue Fixation”, J Biomater Sci Polymer Edn 1999;10: 63-78.
Sung HW et al., “Mechanical Properties of a Porcine Aortic Valve Fixed With a Naturally Occurring Crosslinking Agent” Biomaterials 1999; 20: 1759-72.
Tsai CC et al., “In Vitro Evaluation of the Genotoxicity of a Naturally Occurring Crosslinking Agent (Genipin) for Biological Tissue Fixation” J Biomed Mater Res 2000; 52: 58-65.
Sung HW et al., “Fixation of Biological Tissues With a Naturally Occurring Crosslinking Agent Fixation Rate and Effects of pH, Temperature, and Initial Fixative Concentration” J Biomed Mater Res 2000; 52: 77-87.
Sung HW et al., “Feasibility Study of a Natural Crosslinking Reagent for Biological Tissue Fixation” J Biomed Mater Res 1998; 42: 560-567.
Huang LH et al., “Biocompatibility Study of a Biological Tissue Fixed With a Naturally Occurring Crosslinking Reagent” J Biomed Mater Res 1998; 42: 568-576.
Sung HW et al., “In Vitro Surface Characterization of a Biological Patch Fixed With a Naturally Occurring Crosslinking Agent” Biomaterials 2000; 21: 1353-1362.
Sung HW et al.; “Crosslinking Characteristics and Mechanical Properties of a Bovine Pericardium Fixed With a Naturally Occurring Crosslinking Agent” J Biomed Mater Res 1999; 47: 116-126.
Chang Y et al., “Reconstruction of the Right Ventricular Outflow Tract With a Bovine Jugular Vein Graft Fixed With a Naturally Occurring Crosslinking Agent (Genipin) in a Canine Model” J Thorac Cardiovasc Surg 2001; 122: 1208-18.
Sung HW et al., “Extraction of a Naturally Occurring Crosslinking Agent (Genipin) from Gardenia Fruits and its Applications in Biological Tissue Fixation” Biomaterials and Drug Delivery Toward New Millenium (Ed. KD Park et al.) Han Rin Wen Publishing pp. 623-632 (2000).
Tsai CC et al., “Effects of Heparin Immobilization on the Surface Characteristics of a Biological Tissue Fixed With a Naturally Occurring Crosslinking Agent (Genipin)—an In Vitro Study” Biomaterials 2001; 23: 523-533.
Courtman DW et al., “Development of a Pericardial Acellular Matrix Biomaterial. Biochemical and Mechanical Effects of Cell Extraction” J Biomed Mater Res 1994; 23: 655-666.
Wilson GJ et al., “Acellular Matrix Allograft Small Caliber Vascular Prostheses” Trans Am Soc Artif Intern Organs 1990; 36: 340-343.
Malone JM et al., “Detergent-Extracted Small-Diameter Vascular Prostheses” J Vasc Surg 1984; 1: 181-191.
Liang Huang-Chien
Sung Hsing-Wen
Tu Hosheng
GP Medical, Inc.
Krishnan Ganapathy
Wilson James O.
LandOfFree
Acellular biological material chemically treated with genipin does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Acellular biological material chemically treated with genipin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Acellular biological material chemically treated with genipin will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3628458