Accurate method to characterize airway nitric oxide using...

Details Accurate method to characterize airway nitric oxide using... Accurate method to characterize airway nitric oxide using...

2008-09-23

2008-09-23

Nasser, Jr., Robert L. (Department: 3735)

Surgery

Diagnostic testing

Respiratory

C600S529000, C600S533000

Reexamination Certificate

active

11636027

ABSTRACT:
An apparatus and method to characterize NO gas exchange dynamics in human lungs comprising the steps of: (1) performing a series of breath hold maneuvers of progressively increasingly breath hold times, each breath hold maneuver comprising a) inhaling a gas, b) holding a breath for a selected time duration, and c) exhaling at a flow rate which is uncontrolled but which is effective to ensure evacuation of the airway space and (2) measuring airway NO parameters during consecutive breath hold maneuvers. As a result disease states of the lungs are diagnosed using the measured airway NO parameters.

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patent: 6866637 (2005-03-01), George et al.
Kharitonov SA and Barnes PJ. Nasal Contribution to exhaled nitric oxide during exhalation against resistance or during breath holding. Thorax 52:540-544, 1997.
Shin HW, Condorelli P, and George SC. A new and more accurate technique to characterize airway nitric oxide using different breath-hold times. J Appl Physiol 98:1869-1877, 2005.
Shin HW, Condorelli P, George SC. Examining axial diffusion of nitric oxide in the lungs using heliox and breath hold. J Appl Physiol 100: 623-630, 2006.

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