Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Reexamination Certificate
2005-01-26
2009-02-03
Ketter, James S (Department: 1636)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
C435S320100, C435S235100, C435S363000, C435S366000, C435S367000
Reexamination Certificate
active
07485458
ABSTRACT:
Accessory functions capable of supporting efficient recombinant AAV (rAAV) virion production in a suitable host cell are provided. The accessory functions are in the form of one or more vectors that are capable of being transferred between cells. Methods of producing rAAV virions are also provided. The methods can be practiced to produce commercially significant levels of rAAV particles without also generating significant levels of infectious helper virus or other contaminating by-products.
REFERENCES:
patent: 5173414 (1992-12-01), Lebkowski et al.
patent: 5436146 (1995-07-01), Shenk et al.
patent: 5753500 (1998-05-01), Shenk et al.
patent: 5872005 (1999-02-01), Wang et al.
patent: 5945335 (1999-08-01), Colosi
patent: 6004797 (1999-12-01), Colosi
patent: 6268213 (2001-07-01), Samulski et al.
patent: 2 707 664 (1995-01-01), None
patent: WO 96/22378 (1996-07-01), None
patent: WO 96/40240 (1996-12-01), None
Colosi, Peter, et al., “AAV Vectors can be Efficiently Produced Without Helper Virus,” Blood, vol. 86, No. 10, Suppl. 01, XP000614696, Nov. 15, 1995, p. 627A.
Carter, “Adeno-Associated Virus Helper Functions,” Handbook of Paroviruses 1(13):255-282 (1990).
Carter, et al., “Properties of an Adenovirus Type 2 Mutant, Ad2dl807, Having a Deletion Near the Right-Hand Genome Terminus: Failure to Help AAV Replication,” Virology 126:505-516 (1983).
Georg-Fries, et al., “Analysis of Proteins, Helper Dependence, and Seroepidemiology of a New Human Parovirus,” Virology 134:64-71 (1984).
Handa, “Complementation of Adeno-Associated Virus Growth with Temperature-Sensitive Mutants of Human Adenovirus Typed 12 and 5,” J. Gen. Virol. 29:239-242 (1975).
Hermonat, et al., “Use of Adeno-Associated Virus as a Mammalian DNA Cloning Vector: Transduction of Neomycin Resistance into Mammalian Tissue Culture Cells,” PNAS 81:6466-6470 (1984).
Ishibashi, “The Potentiation of Type A Adeno-Associated Virus by Temperature-Sensitive Conditional-Lethal Mutants of CELO Virus at the Restrictive Temperature,” Virology 45:317-320 (1971).
Ito, “Adeno-Associated Satellite Virus Growth Supported by a Temperature-Sensitive Mutant of Human Adenovirus,” J. Gen. Virol. 9:243-245 (1970).
Janik, et al., “Locations of Adenovirus Genes Required for the Replication of Adenovirus-Associated Virus,” Proc. Natl. Acad. Sci. USA 78(3):1925-1929 (1981).
Jay, et al., “Eukaryotic Translational Control: Adeno-Associated Virus Protein Synthesis is Affected by a Mutation in the Adenovirus DNA-Binding Protein,” Proc. Natl. Acad. Sci. USA 78(5):2927-2931 (1981).
Javier, “Adenovirus Type 9 E4 Open Reading Frame 1 Encodes a Transforming Protein Requires for the Production of Mammary Tumors in Rats,” Journal of Virology 68(6):3917 (1994).
Klessig, et al., “Introduction, Stable Integration, and Controlled Expression of a Chimeric Adenovirus Gene Whose Product is Toxic to the Recipient Human Cell,”Molecular and Cellular Biology 4(7):1354 (1984).
Laughlin, et al., “Effect of Deletions in Adenovirus Early Region 1 Genes Upon Replication of Adeno-Associated Virus,” J. Virol. 41(3):868-876 (1982).
McPherson, et al., “Human Cytomegalovirus Completely Helps Adeno-Associated Virus Replication,” Virology 147:217-222 (1985).
Mishra, et al., “Adeno-Associated Virus DNA Replication is Induced by Genes that are Essential for HSV-1 DNA Synthesis,” Virology 179:632-639 (1990).
Myers, et al., “Adenovirus Helper Function for Growth of Adeno-Associated Virus: Effect of Temperature-Sensitive Mutations in Adenovirus Early Gene Region 2,” J. Virol. 35(1):65-75 (1980).
Myers, et al., “Adeno-Associated Virus Replication,” J. Biol. Chem. 256(2):567-570 (1981).
Moore, et al., “Oncogenic Potential of the Adenovirus E4orf6 Protein,” Proc. Natl. Acad. Sci. USA 93:11295-11301 (1996).
Ostrove, et al., “Adenovirus Early Region 1b Gene Function Required for Rescue of Latent Adeno-Associated Virus,” Virology 104:502-505 (1980).
Richardson, et al., “A Cascade of Adenovirus Early Functions is Required for Expression of Adeno-Associated Virus,” Cell 27(2):133-141 (1981).
Rolling, et al., “AAV as a Viral Vector for Human Gene Therapy,” Molecular Biotechnology 3:9-15 (1995).
Samulski, et al., “Helper-Free Stocks of Recombinant Adeno-Associated Viruses: Normal Integration Does Not Require Viral Gene Expression,” Journal of Virology 3822-3828 (1989).
Scaria, et al., “Complementation of a Human Adenovirus Early Region 4 Deletion Mutant in 293 Cells Using Adenovirus-Polylysine-DNA Complexes,” Gene Therapy 2(4):295-298 (1995).
Schlehofer, et al., “Vaccinia Virus, Herpes Simplex Virus, and Carcinogens Induce DNA Amplification in a Human Cell Line and Support Replication of a Helpervirus Dependant Parvovirus,” Virology 152:110-117 (1986).
Straus, et al., “DNA-Minus Temperature-Sensitive Mutants of Adenovirus Type 5 Help Adinovirus-Associated Virus Replication,” J. Virology 14:140-148 (1976).
Wang, et al., “A Packaging Cell Line for Propagation of Recombinant Adenovirus Vectors Containing Two Lethal Gene-Region Deletions,” Gene Therapy 2:775-783 (1995).
Weindler, et al., “A Subset of Herpes Simplex Virus Replication Genes Provides Helper Functions for Productive Adeno-Associated Virus Replication,” J. Virology 65(5):2476-2483 (1991).
Weiss, et al., “Human Adenovirus Early Region 4 Open Reading Frame 1 Genes Encode Growth-Transforming Proteins That May Be Distinctly Related to dUTP Pyrophosphatase Enzymes,” Journal of Virology 71(3):1857-1870 (1997).
Xiao, et al., “Production of High-Titer Recombinant Adeno-Associated Virus Vectors in the Absence of Helper Adenovirus,” Journal of Virology 72(3):2224-2232 (1998).
Genzyme Corporation
Ketter James S
Robins & Pasternak LLP
LandOfFree
Accessory functions for use in recombinant AAV virion... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Accessory functions for use in recombinant AAV virion..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Accessory functions for use in recombinant AAV virion... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4067217