Accessory functions for use in recombinant AAV virion...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

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C435S320100, C435S363000, C435S366000, C435S367000

Reexamination Certificate

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06897063

ABSTRACT:
Accessory functions capable of supporting efficient recombinant AAV (rAAV) virion production in a suitable host cell are provided. The accessory functions are in the form of one or more vectors that are capable of being transferred between cells. Methods of producing rAAV virions are also provided. The methods can be practiced to produce commercially significant levels of rAAV particles without also generating significant levels of infectious helper virus or other contaminating by-products.

REFERENCES:
patent: 5436146 (1995-07-01), Shenk et al.
patent: 5872005 (1999-02-01), Wang et al.
patent: 6268213 (2001-07-01), Samulski et al.
patent: WO 9640240 (1996-12-01), None
Carter, “Adeno-Associated Virus Helper Functions,”Handbook of Paroviruses1(13):255-282 (1990).
Carter et al., “Properties of an Adenovirus Type 2 Mutant, Ad2dI807, Having a Deletion Near the Right-hand Genome Terminus: Failure to Help AAV Replication,”Virology126:505-516 (1983).
Georg-Fries et al., “Analysis of Proteins, Helper Dependance, and Seroepidemiology of a New Human Parovirus,”Virology 134:64-71 (1984).
Handa, “Complementation of Adeno-Associated Virus Growth with Temperature-Sensitive Mutants of Human Adenovirus Types 12 and 5,”J. Gen. Virol. 29:239-242 (1975).
Hermonat et al., “Use of Adeno-Associated Virus as a Mammalian DNA Cloning Vector: Transduction of Neomycin Resistance into Mammalian Tissue Culture Cells,”PNAS 8166-6470 (1984).
Ishibashi, “The Potentiation of Type A Adeno-Associated Virus by Temperature-Sensitive Conditional-Lethal Mutants of CELO Virus at the Restrictive Temperature,”Virology 45:317-320 (1971).
Ito, M., “Adeno-associated Satellite Virus Growth Supported by a Temperature-sensitive Mutant of Human Adenovirus,”J. Gen. Virol. 9:243-245 (1970).
Janik et al., “Locations of Adenovirus genes Required for the Replication of Adenovirus-associated Virus,”Proc. Natl. Acad. Sci.USA 78(3):1925-1929 (1981).
Jay et al., “Eukaryotic Translational Control: Adeno-associated Virus Protein Synthesis is Affected by a Mutation in the Adenovirus DNA-binding Protein,”Proc. Natl. Acad. Sci. USA 78(5):2927-2931 (1981).
Klessig et al.,Molecular and Cellular Biology 4(7):1354-1362 (1984).
Laughlin et al., “Effect of Deletions in Adenovirus Early Region 1 Genes Upon Replication of Adeno-Associated Virus,”J. Virol. 41(3):868-876 (1982).
McPherson et al., “Human Cytomegalovirus Completely Helps Adeno-Associated Virus Replication,”Virology147:217-222 (1985).
Mishra et al., “Adeno-Associated Virus DNA Replication is Induced by Genes that are Essential for HSV-1 DNA Synthesis,”Virology. 179:632-639 (1990).
Myers et al., “Adeno-Associated Virus Replication,”J. Biol. Chem. 256:567-570 (1981).
Myers et al., “Adenovirus Helper Function for Growth of Adeno-Associated Virus: Effect of Temperature-Sensitive Mutations in Adenovirus Early Gene Region 2,”J. Virol. 35(1):65-75 (1980).
Ostrove et al., “Adenovirus Early Region 1b Gene Function Required for Rescue of Latent Adeno-Associated Virus,”Virology 104:502-505 (1980).
Richardson et al., “A cascade of Adenovirus Early Functions is Required for Expression of Adeno-Associated Virus,”Cell 27(2):133-141 (1981).
Samulski et al., “Helper-Free Stocks of Recombinant Adeno-Associated Viruses: Normal Integration Does Not Require Viral Gene Expression”Journal of Virology, pp. 3822-3828 (1989).
Scaria et al.,Gene Therapy 2:295-298 (1995).
Schlehofer et al., “Vaccinia Virus, Herpes Simplex Virus, and Carcinogens Induce DNA Amplification in a Human Cell Line and Support Replication of a Helpervirus Dependent Parvovirus,”Virology 152:110-117 (1986).
Straus et al., “DNA-Minus Temperature-Sensitive Mutants of Adenovirus Type 5 Help Adneovirus-Associated Virus Replication,”J. Virology 17:140-148 (1976).
Wang et al., “A Packaging Cell Line for Propagation of Recombinant Adenovirus Vectors Containing Two Lethal Gene Region Deletions,”Gene Therapy 2:775-783 (1995).
Weindler et al., “A Subset of Herpes Simplex Virus Replication Genes Provides Helper Functions for Productive Adeno-Associated Virus Replication,”J. Virology 65(5):2476-2483 (1991).
Rolling et al., “AAV as a Viral Vector for Human Gene Therapy,” Molecular Biotechnology, 3:9-15 (1995).

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